TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 467.945 | Formula: C25H26ClN3O4
H donors: 4 H acceptors: 4 LogP: 5.87 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@@H]([C@@H](C(=O)O)NC(=O)c1cc2ccccc2cc1NC(=O)Nc1c(C)cccc1Cl)C
InChi: 1S/C25H26ClN3O4/c1-4-14(2)22(24(31)32)28-23(30)18-12-16-9-5-6-10-17(16)13-20(18)27-25(33)29-21-15(3)8-7-11-19(21)26/h5-14,22H,4H2,1-3H3,(H,28,30)(H,31,32)(H2,27,29,33)/t14-,22-/m0/s1
InChiKey: BRGGPINUBORHSD-FPTDNZKUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0067	0.1494	0.4504
Onchocerca volvulus		0.0067	0.1494	0.4258
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	neuropeptide s receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0067	0.1494	0.4258
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0367	0.1108
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0067	0.1494	0.1409
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	nAChR subunit	0.002	0.0142	0.0044
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0067	0.1494	0.1409
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Brugia malayi	putative neuropeptide receptor	0.0067	0.1494	0.4504
Schistosoma mansoni	glycogen phosphorylase	0.013	0.3316	0.325
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0067	0.1494	0.1409
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.3316	1
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0142	0.0044
Schistosoma mansoni	nAChR subunit	0.002	0.0142	0.0044
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1002	0.0912
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.002	0.0142	0.0044
Echinococcus multilocularis	neuropeptide receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	g-protein coupled receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0067	0.1494	0.1409
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0142	0.0429
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.148	0.1395
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.148	0.1395
Schistosoma mansoni	neuropeptide receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Onchocerca volvulus		0.0067	0.1494	0.4258
Brugia malayi	neuropeptide F receptor	0.0067	0.1494	0.4504
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0067	0.1494	0.1409
Schistosoma mansoni	neuropeptide f receptor 76f	0.0067	0.1494	0.1409
Brugia malayi	Cation transporter family protein	0.002	0.0142	0.0429
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.002	0.0142	0.0044
Echinococcus multilocularis	neuropeptide Y receptor	0.0067	0.1494	0.1409
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	neuropeptide s receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	neuropeptide receptor	0.0067	0.1494	0.1409
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.3316	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	fmrfamide receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	biogenic amine 5HT receptor	0.0067	0.1494	0.1409
Onchocerca volvulus		0.0067	0.1494	0.4258
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	LGC-31 protein	0.002	0.0142	0.0429
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0142	0.0044
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Brugia malayi	G-protein coupled receptor	0.0067	0.1494	0.4504
Brugia malayi	RE15519p	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0056	0.1193	0.7924
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0067	0.1494	0.1409
Onchocerca volvulus		0.0067	0.1494	0.4258
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0142	0.0429
Echinococcus multilocularis	G protein coupled receptor 139	0.0067	0.1494	0.1409
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.148	1
Schistosoma mansoni	lamin	0.0028	0.0367	0.0271
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0142	0.0429
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1002	0.0912
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.1494	0.1409
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.1494	0.1409
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0067	0.1494	0.1409
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.002	0.0142	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	orexin receptor type 2	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1002	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0142	0.0044
Onchocerca volvulus		0.0067	0.1494	0.4258
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.002	0.0142	0.0429
Onchocerca volvulus		0.0067	0.1494	0.4258
Echinococcus granulosus	somatostatin receptor	0.0067	0.1494	0.1409
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.148	1
Echinococcus multilocularis	fmrfamide receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.1494	0.1409
Echinococcus granulosus	serotonin receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	serotonin receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	histamine h1 receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	G-protein coupled receptor	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	intermediate filament protein	0.0028	0.0367	0.0271
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.3316	0.325
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0067	0.1494	0.4504
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0067	0.1494	0.1409
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Schistosoma mansoni	amine GPCR	0.0067	0.1494	0.1409
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Brugia malayi	neuropeptide F receptor	0.0067	0.1494	0.4504
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0142	0.0429
Echinococcus granulosus	fmrfamide receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	G protein coupled receptor 139	0.0067	0.1494	0.1409
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0099	0.0298
Brugia malayi	G protein-coupled receptor F59B2.13	0.0067	0.1494	0.4504
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0142	0.0044
Loa Loa (eye worm)	G-protein coupled receptor	0.0067	0.1494	0.4504
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.002	0.0142	0.0044
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.002	0.0142	0.0044
Echinococcus granulosus	7TM GPCR rhodopsin	0.0067	0.1494	0.1409
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.3316	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1002	0.0912
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0142	0.0429
Echinococcus granulosus	7tm_1 domain containing protein	0.0067	0.1494	0.1409
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.002	0.0142	0.0044
Echinococcus multilocularis	sex peptide receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1002	0.0912
Schistosoma mansoni	nAChR subunit	0.002	0.0142	0.0044
Echinococcus multilocularis	g protein coupled receptor	0.0067	0.1494	0.1409
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0067	0.1494	0.1409
Echinococcus granulosus	neuropeptide FF receptor 2	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Echinococcus granulosus	hypothetical protein	0.0067	0.1494	0.1409
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	opsin-like receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.3316	0.325
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.1494	0.1409
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0367	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.3316	0.325
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0099	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0067	0.1494	0.1409
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.148	1
Brugia malayi	Dopamine receptor	0.0067	0.1494	0.4504
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0367	0.0271
Brugia malayi	excitatory GABA receptor EXP-1A	0.002	0.0142	0.0429
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0142	0.0044
Echinococcus multilocularis	g-protein coupled receptor	0.0067	0.1494	0.1409
Schistosoma mansoni	hypothetical protein	0.0067	0.1494	0.1409
Schistosoma mansoni	glycogen phosphorylase	0.013	0.3316	0.325
Schistosoma mansoni	opsin-like receptor	0.0067	0.1494	0.1409
Schistosoma mansoni	biogenic amine receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0067	0.1494	0.4504
Schistosoma mansoni	biogenic amine receptor	0.0067	0.1494	0.1409
Brugia malayi	putative neuropeptide receptor NPR1	0.0067	0.1494	0.4504
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0142	0.0044
Loa Loa (eye worm)	neuropeptide F receptor	0.0067	0.1494	0.4504
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.1193	0.1105
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0067	0.1494	0.1409
Brugia malayi	G protein-coupled receptor	0.0067	0.1494	0.4504
Brugia malayi	carbohydrate phosphorylase	0.013	0.3316	1
Brugia malayi	AKH receptor	0.0067	0.1494	0.4504
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.002	0.0142	0.0429
Loa Loa (eye worm)	melatonin receptor type 1A	0.0067	0.1494	0.4504
Echinococcus granulosus	neuropeptide receptor	0.0067	0.1494	0.1409
Brugia malayi	sulfakinin receptor protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1193	0.3401
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0067	0.1494	0.1409
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.3316	0.325
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0099	0.5
Schistosoma mansoni	amine GPCR	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.002	0.0142	0.0044
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0067	0.1494	0.1409
Schistosoma mansoni	amine GPCR	0.0067	0.1494	0.1409
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0067	0.1494	0.1409
Onchocerca volvulus		0.0067	0.1494	0.4258
Loa Loa (eye worm)	neuropeptide F receptor	0.0067	0.1494	0.4504
Schistosoma mansoni	growth hormone secretagogue receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	neuropeptides capa receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0067	0.1494	0.1409
Brugia malayi	larval opioid receptor	0.0067	0.1494	0.4504
Echinococcus multilocularis	somatostatin receptor	0.0067	0.1494	0.1409
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.3316	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0067	0.1494	0.1409
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.1193	0.7924
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Echinococcus granulosus	neuropeptide Y receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0067	0.1494	0.1409
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Echinococcus multilocularis	nAChR subunit	0.002	0.0142	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0367	0.1108
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.002	0.0142	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.148	0.1395
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	orexin receptor type 2	0.0067	0.1494	0.1409
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.1002	0.3022
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	biogenic amine receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0142	0.0044
Echinococcus granulosus	sex peptide receptor	0.0067	0.1494	0.1409
Brugia malayi	Serotonin receptor	0.0067	0.1494	0.4504
Echinococcus multilocularis	neuropeptides capa receptor	0.0067	0.1494	0.1409
Brugia malayi	Serotonin receptor	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	neuropeptide receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0142	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	lamin dm0	0.0028	0.0367	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1002	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	hypothetical protein	0.0067	0.1494	0.1409
Brugia malayi	Dopamine receptor protein 1	0.0067	0.1494	0.4504
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0142	0.0429
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Schistosoma mansoni	lamin	0.0028	0.0367	0.0271
Brugia malayi	Dopamine receptor protein 2	0.0067	0.1494	0.4504
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.3316	1
Brugia malayi	follicle stimulating hormone receptor	0.0067	0.1494	0.4504
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0142	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	neuropeptide receptor	0.0067	0.1494	0.1409
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.148	0.1395
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0067	0.1494	0.4504
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	g protein coupled receptor	0.0067	0.1494	0.1409
Onchocerca volvulus		0.0067	0.1494	0.4258
Schistosoma mansoni	hypothetical protein	0.0067	0.1494	0.1409
Giardia lamblia	Glycogen phosphorylase	0.013	0.3316	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.002	0.0142	0.0044
Echinococcus granulosus	glycogen phosphorylase	0.013	0.3316	0.325
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.148	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.1494	0.1409
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0067	0.1494	0.1409
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0367	0.1108
Echinococcus multilocularis	neuropeptide receptor A26	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0142	0.0044
Echinococcus granulosus	tm gpcr rhodopsin	0.0067	0.1494	0.1409
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0142	0.0044
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0067	0.1494	0.4258
Echinococcus granulosus	lamin	0.0028	0.0367	0.0271
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Onchocerca volvulus		0.0067	0.1494	0.4258
Echinococcus granulosus	neuropeptide receptor A26	0.0067	0.1494	0.1409
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Schistosoma mansoni	hypothetical protein	0.0067	0.1494	0.1409
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.002	0.0142	0.0044
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0067	0.1494	0.4504
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0142	0.0044
Onchocerca volvulus		0.0067	0.1494	0.4258
Brugia malayi	ORL1-like opioid receptor	0.0067	0.1494	0.4504
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0142	0.0044
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	dro:myosuppressin receptor	0.0067	0.1494	0.1409
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.1002	0.3022
Schistosoma mansoni	neuropeptide receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Echinococcus granulosus	g protein coupled receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0142	0.0044
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0142	0.0429
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0142	0.0429
Onchocerca volvulus		0.0067	0.1494	0.4258
Echinococcus multilocularis	lamin	0.0028	0.0367	0.0271
Echinococcus granulosus	neuropeptide Y receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	nAChR subunit	0.002	0.0142	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	neuropeptide receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.002	0.0142	0.0429
Brugia malayi	Cation transporter family protein	0.002	0.0142	0.0429
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0099	0.5
Entamoeba histolytica	glycogenphosphorylase, putative	0.0056	0.1193	0.3401
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.002	0.0142	0.0429
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Onchocerca volvulus		0.0067	0.1494	0.4258
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Brugia malayi	GnHR receptor homolog	0.0067	0.1494	0.4504
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.002	0.0142	0.0429
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0067	0.1494	0.1409
Echinococcus granulosus	lamin dm0	0.0028	0.0367	0.0271
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0142	0.0044
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0142	0.0044
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0067	0.1494	0.4504
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0099	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0067	0.1494	0.1409
Onchocerca volvulus		0.0067	0.1494	0.4258
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Onchocerca volvulus		0.0028	0.0367	0.0709
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0067	0.1494	0.4504
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0142	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	neuropeptides capa receptor	0.0067	0.1494	0.1409
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0067	0.1494	0.1409
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0067	0.1494	0.1409
Echinococcus multilocularis	musashi	0.0028	0.0367	0.0271
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.148	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1002	0.0912
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.002	0.0142	0.0429
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.148	1
Onchocerca volvulus		0.0067	0.1494	0.4258
Schistosoma mansoni	amine GPCR	0.0067	0.1494	0.1409
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0067	0.1494	0.4504
Schistosoma mansoni	adenoreceptor	0.0067	0.1494	0.1409
Brugia malayi	intermediate filament protein	0.0028	0.0367	0.1108
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0099	0.5
Onchocerca volvulus		0.0067	0.1494	0.4258
Echinococcus granulosus	nAChR subunit	0.002	0.0142	0.0044
Echinococcus multilocularis	neuropeptide Y receptor	0.0067	0.1494	0.1409
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.002	0.0142	0.0044
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.3316	1
Brugia malayi	Cation transporter family protein	0.002	0.0142	0.0429
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0142	0.0429
Schistosoma mansoni	nAChR subunit	0.002	0.0142	0.0044
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	nAChR subunit	0.002	0.0142	0.0044
Schistosoma mansoni	nAChR subunit	0.002	0.0142	0.0044
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.002	0.0142	0.0429
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.3316	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0067	0.1494	0.1409
Echinococcus granulosus	rhodopsin orphan GPCR	0.0067	0.1494	0.1409
Schistosoma mansoni	opsin-like receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus granulosus	g protein coupled receptor	0.0067	0.1494	0.1409
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0142	0.0429
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0142	0.0044
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.002	0.0142	0.0044
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.002	0.0142	0.0044
Onchocerca volvulus		0.0028	0.0367	0.0709
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0067	0.1494	0.1409
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0067	0.1494	0.1409
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.002	0.0142	0.0429
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Echinococcus multilocularis	neuropeptides capa receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0067	0.1494	0.1409
Loa Loa (eye worm)	TYRA-2 protein	0.0067	0.1494	0.4504
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0099	0.5
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.002	0.0142	0.0429
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0142	0.0044
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.002	0.0142	0.0429
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0099	0.0298
Echinococcus granulosus	allatostatin A receptor	0.0067	0.1494	0.1409
Brugia malayi	hypothetical protein	0.0067	0.1494	0.4504
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1193	0.3401
Brugia malayi	Melatonin receptor type 1A	0.0067	0.1494	0.4504
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0067	0.1494	0.1409
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0142	0.0044
Onchocerca volvulus		0.0067	0.1494	0.4258
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0429
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0099	0.5
Schistosoma mansoni	amine GPCR	0.0067	0.1494	0.1409
Brugia malayi	G-protein coupled receptor	0.0067	0.1494	0.4504
Onchocerca volvulus		0.0067	0.1494	0.4258
Schistosoma mansoni	myosin xvIII	0.0067	0.1494	0.1409
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.002	0.0142	0.0429
Schistosoma mansoni	neuropeptide F-like receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0353	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0142	0.0429
Echinococcus granulosus	glycogen phosphorylase	0.013	0.3316	0.325
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Echinococcus multilocularis	serotonin receptor	0.0067	0.1494	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1494	0.4504
Schistosoma mansoni	neuropeptide F-like receptor	0.0067	0.1494	0.1409

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.28 uM	Inhibition of human glycogen phosphorylase alpha	ChEMBL.	18554908
IC50 (binding)	= 1.1 uM	Inhibition of human glycogen phosphorylase alpha in HepG2 cells assessed as inhibition of forskolin-induced glycogenolysis after 60 mins	ChEMBL.	18554908

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL453312

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1182518