Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4201 | 0.4201 |
Trichomonas vaginalis | importin beta-1, putative | 0.0025 | 0.0075 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0075 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0031 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.4683 | 0.4683 |
Brugia malayi | Importin beta-1 subunit | 0.0031 | 0.0266 | 0.1253 |
Echinococcus granulosus | importin subunit beta 1 | 0.0031 | 0.0266 | 0.0266 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0025 | 0.0075 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0075 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0107 | 0.2729 | 0.2729 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0266 | 0.0266 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0075 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0031 | 0.0266 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0031 | 0.0266 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0266 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0031 | 0.0266 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0266 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0031 | 0.0266 | 0.0266 |
Leishmania major | importin beta-1 subunit, putative | 0.0025 | 0.0075 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0163 | 0.4553 | 0.4553 |
Brugia malayi | RNA, U transporter 1 | 0.0088 | 0.2121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2858 | 0.2858 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.351 nM | Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by radiometric assay | ChEMBL. | 19053825 |
Ki (binding) | = 0.557 nM | Inhibition of PSMA in human LNCaP cell extract using [3H]NAAG by fluorescence-based assay | ChEMBL. | 19053825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.