Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | monoamine oxidase | 0.00157126 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.00157126 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.00157126 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.00978849 | 0.89855 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00978849 | 0.89855 | 0.89855 |
Onchocerca volvulus | 0.0107163 | 1 | 0.5 | |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.00157126 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.00157126 | 0 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.00157126 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.00157126 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00249902 | 0.10145 | 0.10145 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.00157126 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.00157126 | 0 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.00157126 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.00157126 | 0 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.00157126 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.00157126 | 0 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.00978849 | 0.89855 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.00978849 | 0.89855 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.00157126 | 0 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.00157126 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107163 | 1 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.00157126 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.00157126 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.00157126 | 0 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.00157126 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.00157126 | 0 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0107163 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.00157126 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00978849 | 0.89855 | 0.89855 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.00249902 | 0.10145 | 0.10145 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.00157126 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected mice (Mus musculus) macrophage by reporter dye assay | ChEMBL. | 17698622 |
IC50 (functional) | = 14.2 uM | Trypanocidal activity against Trypanosoma brucei rhodesiense STIB 900 infected in mouse macrophage by reporter dye assay | ChEMBL. | 17698622 |
IC50 (functional) | < 30 uM | Antileishmanial activity against Leishmania donovani MHOMET-67/L82 amastigotes infected in mouse macrophage by reporter dye assay | ChEMBL. | 17698622 |
IC50 (functional) | < 30 uM | Trypanocidal activity against Trypanosoma cruzi Tulahuen C4 trypomastigotes infected in mouse macrophage by reporter dye assay | ChEMBL. | 17698622 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 17698622 | ||
Trypanosoma brucei gambiense | 17698622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.