Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cytochrome c | 0.0033 | 0.0881 | 0.0881 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.0033 | 0.0881 | 0.0881 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0067 | 0.2803 | 0.2803 |
Plasmodium falciparum | glutathione reductase | 0.0067 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0255 | 0.0255 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Schistosoma mansoni | cytochrome c | 0.0033 | 0.0881 | 0.0881 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0067 | 0.2803 | 0.2803 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0255 | 0.0908 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0049 | 0.179 | 0.179 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0067 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0255 | 0.0255 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0067 | 0.2803 | 0.2803 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0255 | 0.0255 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0255 | 0.0255 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0255 | 0.0255 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0067 | 0.2803 | 0.2803 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0255 | 0.0255 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma brucei | cytochrome c | 0.0033 | 0.0881 | 0.0881 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0067 | 0.2803 | 0.2803 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0067 | 0.2803 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0255 | 0.0908 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0067 | 0.2803 | 0.2803 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 1 |
Leishmania major | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0067 | 0.2803 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0067 | 0.2803 | 1 |
Toxoplasma gondii | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0255 | 0.0255 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0255 | 0.0908 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0067 | 0.2803 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0067 | 0.2803 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0255 | 0.0908 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.0033 | 0.0881 | 0.3143 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0067 | 0.2803 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0067 | 0.2803 | 0.2803 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0067 | 0.2803 | 0.2803 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0067 | 0.2803 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0255 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0049 | 0.179 | 0.179 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0067 | 0.2803 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0067 | 0.2803 | 1 |
Brugia malayi | Cytochrome c type-1 | 0.0033 | 0.0881 | 0.0881 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0255 | 0.0255 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0067 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0067 | 0.2803 | 0.2803 |
Plasmodium vivax | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0255 | 0.0255 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0067 | 0.2803 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0067 | 0.2803 | 0.2803 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0255 | 0.0255 |
Leishmania major | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0067 | 0.2803 | 0.2803 |
Plasmodium falciparum | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0255 | 0.0255 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0067 | 0.2803 | 0.2803 |
Echinococcus granulosus | cytochrome c | 0.0033 | 0.0881 | 0.0881 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0255 | 0.0908 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0255 | 0.0255 |
Treponema pallidum | NADH oxidase | 0.0067 | 0.2803 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0255 | 0.0908 |
Trypanosoma cruzi | cytochrome c, putative | 0.0033 | 0.0881 | 0.0881 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0255 | 0.0255 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.