Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.2196 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.2196 | 0.8587 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0244 | 0.0955 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0703 | 0.2748 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.2196 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0244 | 0.0955 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0703 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.6204 | 0.6109 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0703 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0703 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.2558 | 0.2371 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0703 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0163 | 0.9731 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0.0244 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.2196 | 0.2001 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0703 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.8998 | 0.8973 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0703 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.2558 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0107 | 0.5936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0703 | 0.047 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0703 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 105 nM | Inhibition of human cloned glutamate carboxypeptidase 2 | ChEMBL. | 19897367 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.