Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.4962 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.071 | 0.5 |
Brugia malayi | hypothetical protein | 0.0079 | 0.4962 | 0.4962 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.4962 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.071 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.4962 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.4962 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.071 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.4962 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.4962 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0143 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.071 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.071 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.2745 | 0.2745 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.071 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.071 | 0.071 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0143 | 1 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.071 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.4962 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.071 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.2745 | 0.2191 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.4962 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 50 % | Antimigratory activity against human MDA-MB-231 at 5 uM after 24 hrs by wound-healing assay | ChEMBL. | 20943398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.