Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.0527 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.4589 | 0.7129 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0527 | 1 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0369 | 0.6437 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0228 | 0.3249 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0165 | 0.1816 | 0.2821 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0173 | 0.201 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0256 | 0.3885 | 0.2529 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.4589 | 0.7129 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0288 | 0.4589 | 0.7129 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0196 | 0.252 | 0.086 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.4589 | 0.7129 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0153 | 0.1547 | 0.2404 |
Onchocerca volvulus | Dual oxidase homolog | 0.0227 | 0.3219 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0173 | 0.201 | 0.0237 |
Echinococcus multilocularis | NMDA receptor | 0.0153 | 0.1547 | 0.2404 |
Echinococcus multilocularis | expressed protein | 0.0369 | 0.6437 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0153 | 0.1547 | 0.2404 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0173 | 0.201 | 0.0237 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0196 | 0.252 | 0.3914 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0173 | 0.201 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0527 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0165 | 0.1816 | 0.4152 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0165 | 0.1816 | 0.2821 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0153 | 0.1547 | 0.2404 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0173 | 0.201 | 0.1381 |
Echinococcus granulosus | glutamate receptor 2 | 0.0196 | 0.252 | 0.3914 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0196 | 0.252 | 0.3914 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0527 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0173 | 0.201 | 0.3122 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0173 | 0.201 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0173 | 0.201 | 0.3122 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0135 | 0.1146 | 0.1781 |
Brugia malayi | Blistered cuticle protein 3 | 0.0227 | 0.3219 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0165 | 0.1816 | 0.4152 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0227 | 0.3219 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0165 | 0.1816 | 0.2821 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0173 | 0.201 | 0.1381 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.4589 | 0.7129 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0176 | 0.2069 | 0.3215 |
Schistosoma mansoni | glutamate receptor kainate | 0.0256 | 0.3885 | 0.2529 |
Leishmania major | carbonic anhydrase-like protein | 0.0173 | 0.201 | 0.1585 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0228 | 0.3249 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0299 | 0.4856 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0196 | 0.252 | 0.3914 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0173 | 0.201 | 0.496 |
Echinococcus granulosus | glutamate receptor 2 | 0.0135 | 0.1146 | 0.1781 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0173 | 0.201 | 0.496 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0288 | 0.4589 | 0.7129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 30000 nM | The compound was tested for cytotoxic activity using standard L1210 cell based cytotoxicity assay | ChEMBL. | 10843206 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.