Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.6438 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0112 | 0.3799 | 0.5 |
Echinococcus multilocularis | lysosomal protective protein | 0.0112 | 0.3799 | 0.3799 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0112 | 0.3799 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.6668 | 0.6668 |
Onchocerca volvulus | 0.0114 | 0.3945 | 0.0551 | |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.6438 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0112 | 0.3799 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.8 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.6438 | 0.6438 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0101 | 0.2993 | 0.2993 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0112 | 0.3799 | 0.3799 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.6668 | 0.6668 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0112 | 0.3799 | 0.4749 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6668 | 0.6668 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0112 | 0.3799 | 0.3799 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0112 | 0.3799 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.6668 | 0.6668 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0112 | 0.3799 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0112 | 0.3799 | 0.4749 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.6438 | 0.6438 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0112 | 0.3799 | 0.5 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0101 | 0.2993 | 0.2993 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0112 | 0.3799 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.6438 | 0.6438 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0112 | 0.3799 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6668 | 0.6668 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.3799 | 0.3799 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.6668 | 0.6668 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.8 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.