Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0047 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.007 | 0.2191 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0047 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0047 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.2191 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0152 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0132 | 0.8068 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.2191 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0096 | 0.4666 | 0.3536 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.2191 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0096 | 0.4666 | 0.317 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0087 | 0.377 | 0.245 |
Brugia malayi | TAR-binding protein | 0.007 | 0.2191 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.2191 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0087 | 0.377 | 0.2023 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.2191 | 0.0536 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.0418 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.