Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0775385 | 1 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0037987 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0037987 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0037987 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0037987 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0037987 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0037987 | 0 | 0.5 |
Onchocerca volvulus | 0.0037987 | 0 | 0.5 | |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0037987 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0037987 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0037987 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0037987 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0037987 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0775385 | 1 | 1 |
Onchocerca volvulus | 0.0037987 | 0 | 0.5 | |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0037987 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0037987 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0775385 | 1 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0037987 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0037987 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0037987 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0037987 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0037987 | 0 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0775385 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0775385 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0775385 | 1 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0775385 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0775385 | 1 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0037987 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0775385 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0037987 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0037987 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037987 | 0 | 0.5 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19299148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.