Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.2892 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.195 | 0.6742 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.2892 | 0.2892 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.2892 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.6884 | 0.6884 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.195 | 0.6742 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2892 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.3289 | 0.3289 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.195 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1767 | 0.6108 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2892 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.195 | 0.6742 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.6884 | 0.6884 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.195 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.195 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.195 | 0.6742 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1767 | 0.1767 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.3289 | 0.3289 |
Brugia malayi | hypothetical protein | 0.0042 | 0.195 | 0.195 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2892 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0102 | 0.6884 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.2892 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.195 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.2892 | 0.2892 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.2892 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.6884 | 0.6884 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0102 | 0.6884 | 0.6884 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.5 um | PUBCHEM_BIOASSAY: High throughput discovery of novel modulators of ROMK K+ channel activity: Analog Library Testing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.