Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0027 | 0.0286 | 0.0286 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.8071 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Echinococcus granulosus | geminin | 0.015 | 0.8071 | 0.8071 |
Echinococcus multilocularis | geminin | 0.015 | 0.8071 | 0.8071 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0086 | 0.4015 | 0.4015 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.4015 | 0.4015 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0027 | 0.0286 | 0.0286 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0086 | 0.4015 | 0.4015 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.1127 | 0.1397 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0081 | 0.3703 | 0.3703 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.1127 | 0.1397 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0286 | 0.0286 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0081 | 0.3703 | 1 |
Brugia malayi | hypothetical protein | 0.0127 | 0.6615 | 0.6615 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0027 | 0.0286 | 0.0286 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.004 | 0.1127 | 0.1127 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0081 | 0.3703 | 0.4588 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0027 | 0.0286 | 0.0286 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.2289 | 0.2836 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.1127 | 0.1397 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0081 | 0.3703 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0286 | 0.0354 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0081 | 0.3703 | 1 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0081 | 0.3703 | 0.3703 |
Echinococcus multilocularis | GPCR, family 2 | 0.0027 | 0.0286 | 0.0286 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0027 | 0.0286 | 0.0286 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0081 | 0.3703 | 1 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.3703 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.1127 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2289 | 0.2289 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0286 | 0.0354 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0027 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.6615 | 0.6615 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0081 | 0.3703 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0027 | 0.0286 | 0.0286 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0081 | 0.3703 | 0.4588 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0059 | 0.2289 | 0.2289 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.8071 | 1 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0081 | 0.3703 | 1 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0081 | 0.3703 | 0.3703 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0086 | 0.4015 | 0.4015 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0286 | 0.0354 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.1127 | 0.1127 |
Onchocerca volvulus | 0.0127 | 0.6615 | 0.5 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0027 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.004 | 0.1127 | 0.1127 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0286 | 0.0354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2239 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (binding) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.