Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | pyruvate kinase, muscle | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyruvate kinase | pyruvate kinase, muscle | 605 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0074 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0074 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0074 | 1 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0074 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0074 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0074 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0074 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0074 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0074 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0074 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.2011 | 0.2011 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0074 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.2011 | 0.2011 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0074 | 1 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0074 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0074 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0074 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.004 | 0.2011 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0074 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0074 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.004 | 0.2011 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0074 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0074 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.004 | 0.2011 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0074 | 1 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0074 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0074 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: Secondary assay for Activators of Human Pyruvate Kinase M2 isoform. (Class of assay: confirmatory) [Related pubchem assays: 1634, 1631 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.