TDR Targets

Basic information

Technical information

TDR Targets ID: 1234293
Name: N-(3,4-dichlorophenyl)-2-(4-piperidin-1-ylsul fonylpiperazin-1-yl)acetamide
MW: 435.368 | Formula: C17H24Cl2N4O3S
H donors: 1 H acceptors: 3 LogP: 2.24 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(c(c1)Cl)Cl)CN1CCN(CC1)S(=O)(=O)N1CCCCC1
InChi: 1S/C17H24Cl2N4O3S/c18-15-5-4-14(12-16(15)19)20-17(24)13-21-8-10-23(11-9-21)27(25,26)22-6-2-1-3-7-22/h4-5,12H,1-3,6-11,13H2,(H,20,24)
InChiKey: HUKBKDHKEFUZNB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3,4-dichlorophenyl)-2-[4-(1-piperidylsulfonyl)piperazin-1-yl]acetamide
N-(3,4-dichlorophenyl)-2-[4-(1-piperidylsulfonyl)-1-piperazinyl]acetamide
N-(3,4-dichlorophenyl)-2-(4-piperidinosulfonylpiperazin-1-yl)acetamide
N-(3,4-dichlorophenyl)-2-(4-piperidin-1-ylsulfonylpiperazin-1-yl)ethanamide
AP-124/43383617
N-(3,4-dichlorophenyl)-2-[4-(1-piperidinylsulfonyl)-1-piperazinyl]acetamide
ASN 12914272
N-(3,4-Dichloro-phenyl)-2-[4-(piperidine-1-sulfonyl)-piperazin-1-yl]-acetamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0019	0.0388	0.025
Toxoplasma gondii	aldose reductase, putative	0.0062	0.3684	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0018	0.0303	0.0823
Echinococcus granulosus	tissue type plasminogen activator	0.0022	0.0588	0.0842
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.3549	0.3549
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3168	0.8473
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.3549	0.3549
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0388	0.025
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.2086	0.2086
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.3168	0.3168
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0588	0.0588
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.3549	0.3549
Schistosoma mansoni	hypothetical protein	0.0043	0.2262	0.5794
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	1	1
Mycobacterium ulcerans	oxidoreductase	0.0062	0.3684	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.2262	0.5794
Toxoplasma gondii	kringle domain-containing protein	0.0022	0.0588	0.1595
Echinococcus granulosus	GPCR family 2	0.0019	0.0388	0.025
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0062	0.3684	0.3684
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Loa Loa (eye worm)	oxidoreductase	0.0062	0.3684	0.3684
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Schistosoma mansoni	hypothetical protein	0.0041	0.2086	0.5273
Trypanosoma brucei	aldo-keto reductase, putative	0.0062	0.3684	1
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.2262	0.5794
Echinococcus multilocularis	aldo keto reductase	0.0062	0.3684	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0388	0.025
Schistosoma mansoni	hypothetical protein	0.0022	0.0588	0.0842
Trypanosoma cruzi	aldo-keto reductase	0.0062	0.3684	1
Onchocerca volvulus		0.0062	0.3684	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.3168	0.8473
Loa Loa (eye worm)	oxidoreductase	0.0062	0.3684	0.3684
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0062	0.3684	0.3684
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0388	0.025
Entamoeba histolytica	aldose reductase, putative	0.0062	0.3684	1
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0022	0.0588	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0388	0.025
Schistosoma mansoni	pol-related	0.0062	0.3684	1
Loa Loa (eye worm)	oxidoreductase	0.0062	0.3684	0.3684
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0388	0.0388
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Trypanosoma brucei	prostaglandin f synthase	0.0062	0.3684	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3168	0.8473
Giardia lamblia	Aldose reductase	0.0062	0.3684	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0588	0.0588
Leishmania major	aldo-keto reductase-like protein	0.0062	0.3684	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3168	0.8473
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0018	0.0303	0.0303
Onchocerca volvulus		0.0062	0.3684	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0062	0.3684	1
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0018	0.0303	0.0823
Brugia malayi	hypothetical protein	0.0043	0.2262	0.2262
Schistosoma mansoni	hypothetical protein	0.0019	0.0388	0.025
Entamoeba histolytica	hypothetical protein	0.0043	0.2262	0.5794
Loa Loa (eye worm)	oxidoreductase	0.0062	0.3684	0.3684
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Echinococcus granulosus	aldo keto reductase	0.0062	0.3684	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0062	0.3684	1
Entamoeba histolytica	hypothetical protein	0.0043	0.2262	0.5794
Entamoeba histolytica	hypothetical protein	0.0043	0.2262	0.5794
Echinococcus multilocularis	aldo keto reductase	0.0062	0.3684	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0022	0.0588	0.0588
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0388	0.025
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Schistosoma mansoni	aldo-keto reductase	0.0062	0.3684	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.3168	0.8473
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0062	0.3684	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0588	0.0842
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.3168	0.8473
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0388	0.0388
Onchocerca volvulus		0.0062	0.3684	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0062	0.3684	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Leishmania major	prostaglandin f synthase, putative	0.0062	0.3684	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0062	0.3684	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0062	0.3684	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.3684	0.3684
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.2262	0.5794
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Brugia malayi	NADH-dependent xylose reductase	0.0018	0.0303	0.0303
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0388	0.025
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Echinococcus multilocularis	aldo keto reductase	0.0062	0.3684	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0062	0.3684	0.3684
Echinococcus multilocularis	aldehyde reductase	0.0044	0.2305	0.5922
Leishmania major	hypothetical protein, conserved	0.0022	0.0588	0.0842
Toxoplasma gondii	aldo-keto reductase	0.0018	0.0303	0.0823
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	1	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0018	0.0303	0.0303
Echinococcus granulosus	aldo keto reductase	0.0062	0.3684	1
Entamoeba histolytica	aldose reductase, putative	0.0062	0.3684	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0062	0.3684	0.3684
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0388	0.025
Onchocerca volvulus		0.0062	0.3684	1
Mycobacterium leprae	Conserved hypothetical protein	0.0044	0.2305	0.5922
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.2086	0.2086
Trichomonas vaginalis	aldo/keto reductase, putative	0.0062	0.3684	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.3168	0.8473
Giardia lamblia	Aldose reductase	0.0062	0.3684	0.5
Onchocerca volvulus		0.0062	0.3684	1
Echinococcus granulosus	hypothetical protein	0.0062	0.3684	1
Brugia malayi	Kringle domain containing protein	0.0022	0.0588	0.0588
Onchocerca volvulus		0.0022	0.0588	0.1595
Echinococcus granulosus	aldehyde reductase	0.0044	0.2305	0.5922
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Echinococcus granulosus	aldo keto reductase	0.0062	0.3684	1
Echinococcus multilocularis	tissue type plasminogen activator	0.0022	0.0588	0.0842
Entamoeba histolytica	aldose reductase, putative	0.0062	0.3684	1
Onchocerca volvulus		0.0062	0.3684	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0062	0.3684	1
Plasmodium falciparum	cysteine repeat modular protein 1	0.0022	0.0588	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0062	0.3684	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0388	0.0388
Trypanosoma cruzi	aldo/keto reductase, putative	0.0062	0.3684	1
Schistosoma mansoni	aldo-keto reductase	0.0062	0.3684	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0062	0.3684	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0062	0.3684	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0388	0.0388
Loa Loa (eye worm)	oxidoreductase	0.0062	0.3684	0.3684
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.3549	0.3549
Trichomonas vaginalis	aldo-keto reductase, putative	0.0062	0.3684	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.3168	0.3168
Onchocerca volvulus		0.0018	0.0303	0.0823
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0062	0.3684	1
Echinococcus multilocularis	aldo keto reductase	0.0062	0.3684	1
Entamoeba histolytica	hypothetical protein	0.0043	0.2262	0.5794

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1311614

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1234293