Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0869 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0869 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0869 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0869 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0869 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0869 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0869 | 1 | 0.5 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.0869 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 1 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0869 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 1 | 0.5 |
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.0869 | 1 | 0.5 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0869 | 1 | 0.5 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.0869 | 1 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0869 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0869 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0869 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 1 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0869 | 1 | 1 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.0869 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0869 | 1 | 1 |
Loa Loa (eye worm) | NHE-3 | 0.0869 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.