Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | No references | |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | solute carrier family 12 (potassium/chloride transporter), member 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.6644 | 1 |
Brugia malayi | Hypothetical 112.3 kDa protein K02A2.3 in chromosome II | 0.0068 | 0.6644 | 0.6644 |
Loa Loa (eye worm) | solute carrier family 12 member 1 | 0.0067 | 0.6511 | 0.9801 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1495 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1495 | 0.225 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.166 | 0.2499 |
Echinococcus multilocularis | solute carrier family 12 | 0.0068 | 0.6644 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.8505 | 0.8505 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.5149 | 0.775 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.6644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.166 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.5149 | 0.775 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 1 | 1 |
Brugia malayi | Amino acid permease family protein | 0.0034 | 0.1495 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.166 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3155 | 0.4749 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.5149 | 0.775 |
Onchocerca volvulus | 0.0057 | 0.5017 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1495 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.6644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3155 | 0.4749 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.0034 | 0.1495 | 0.1495 |
Brugia malayi | Amino acid permease family protein | 0.0068 | 0.6644 | 0.6644 |
Echinococcus granulosus | solute carrier family 12 | 0.0068 | 0.6644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3155 | 0.4749 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1495 | 0.1495 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.0034 | 0.1495 | 0.1495 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.0068 | 0.6644 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1495 | 0.1495 |
Loa Loa (eye worm) | amino acid permease | 0.0045 | 0.3155 | 0.4749 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1495 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.166 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3155 | 0.4749 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 40 % | Antagonist activity at NKKC1 expressed in human HEK293 cells assessed as [86Rb] uptake at 50 uM after 30 mins by scintillation counting | ChEMBL. | 22727639 |
IC50 (functional) | = 1.2 uM | Antagonist activity at KCC2 expressed in human HEK293 cells assessed as decrease in Tl-stimulated fluorescence increase after 8 mins by fluorescence analysis | ChEMBL. | 22727639 |
IC50 (functional) | = 1.2 um | PUBCHEM_BIOASSAY: Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Rubidium Flux. The purpose of this assay was to test lead compounds identified from thallium flux assays in radioactive rubidium [86Rb] flux assays for inhibition of KCC2 and NKCC1 function in HEK293 cells. (Class of assay: confirmatory) [Related pubchem assays: 1456 ] | ChEMBL. | No reference |
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.