Detailed view for Bm1_43470

Basic information

TDR Targets ID: 235864
Brugia malayi, Hypothetical 112.3 kDa protein K02A2.3 in chromosome II
Source Database / ID:  GenBank

pI: 6.7059 | Length (AA): 915 | MW (Da): 101684 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00324   Amino acid permease
PF03522   Solute carrier family 12

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006811   ion transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
808 887 4hny (C) 778 854 35.00 0.8 0.48 0.442332 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127841)

Species Accession Gene Product
Arabidopsis thaliana AT1G30450   cation-chloride co-transporter 1
Brugia malayi Bm1_43470   Hypothetical 112.3 kDa protein K02A2.3 in chromosome II
Brugia malayi Bm1_37070   Amino acid permease family protein
Caenorhabditis elegans CELE_R13A1.2   Protein KCC-1
Caenorhabditis elegans CELE_K02A2.3   Protein KCC-3
Caenorhabditis elegans CELE_H16O14.1   Protein KCC-2, isoform A
Drosophila melanogaster Dmel_CG5594   kazachoc
Echinococcus granulosus EgrG_000080600   solute carrier family 12
Echinococcus multilocularis EmuJ_000080600   solute carrier family 12
Homo sapiens ENSG00000124067   solute carrier family 12 (potassium/chloride transporter), member 4
Homo sapiens ENSG00000124140   solute carrier family 12 (potassium/chloride transporter), member 5
Homo sapiens ENSG00000113504   solute carrier family 12 (potassium/chloride transporter), member 7
Homo sapiens ENSG00000140199   solute carrier family 12 (potassium/chloride transporter), member 6
Loa Loa (eye worm) LOAG_00512   hypothetical protein
Loa Loa (eye worm) LOAG_13779   hypothetical protein
Loa Loa (eye worm) LOAG_15873   hypothetical protein
Loa Loa (eye worm) LOAG_05226   hypothetical protein
Loa Loa (eye worm) LOAG_15464   hypothetical protein
Loa Loa (eye worm) LOAG_09007   hypothetical protein
Loa Loa (eye worm) LOAG_03124   amino acid permease
Loa Loa (eye worm) LOAG_15958   hypothetical protein
Loa Loa (eye worm) LOAG_15659   hypothetical protein
Loa Loa (eye worm) LOAG_12663   hypothetical protein
Loa Loa (eye worm) LOAG_06826   hypothetical protein
Loa Loa (eye worm) LOAG_14752   hypothetical protein
Loa Loa (eye worm) LOAG_12249   hypothetical protein
Loa Loa (eye worm) LOAG_12908   hypothetical protein
Loa Loa (eye worm) LOAG_04285   hypothetical protein
Mus musculus ENSMUSG00000017756   solute carrier family 12, member 7
Mus musculus ENSMUSG00000017765   solute carrier family 12, member 4
Mus musculus ENSMUSG00000027130   solute carrier family 12, member 6
Mus musculus ENSMUSG00000017740   solute carrier family 12, member 5
Schistosoma japonicum Sjp_0300700   Solute carrier family 12 member 6, putative
Schistosoma japonicum Sjp_0079030   Solute carrier family 12 member 5, putative
Schistosoma mansoni Smp_165670   solute carrier family 12 electroneutral k-cl cotransporter
Schmidtea mediterranea mk4.006152.00   Putative solute carrier family 12, k-cl cotransporter
Schmidtea mediterranea mk4.023514.00  
Schmidtea mediterranea mk4.005696.02   Putative solute carrier family 12, electroneutral k-cl cotransporter
Schmidtea mediterranea mk4.024433.00   Putative solute carrier family 12, k-cl cotransporter
Schmidtea mediterranea mk4.022076.00   Putative solute carrier family 12, k-cl cotransporter
Schmidtea mediterranea mk4.028431.00   Putative solute carrier family 12, k-cl cotransporter
Schmidtea mediterranea mk4.028431.01   Putative solute carrier family 12, k-cl cotransporter
Schmidtea mediterranea mk4.005696.03   Putative solute carrier family 12, k-cl cotransporter
Schmidtea mediterranea mk4.021767.00   Putative solute carrier family 12, k-cl cotransporter

Essentiality

Bm1_43470 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R13A1.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_K02A2.3 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 12 (potassium/chloride transporter), member 5 Compounds References
Rattus norvegicus Solute carrier family 12 member 5 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0049 0.3304 0.3304
0.0763 0.2617 0.2617
0.0402 0.2551 0.2551
0.0513 0.5381 1
0.0099 0.3073 0.6355
0.0883 0.266 1
0.041 0.4999 0.5202
0.0049 0.3095 0.3095
0.0301 0.351 1
0.0998 0.3545 1
0.0998 0.3545 1
0.1413 0.9143 0.9143
0.0657 0.6987 1
0.0998 0.3545 1
0.0998 0.3545 1
0.0883 0.266 1
0.0513 0.5381 1
0.0241 0.3872 1
0.0102 0.5997 1
0.0057 0.3143 0.3143
0.1279 0.8241 0.8232
0.005 0.694 0.934
0.1408 0.9187 0.9187
0.1408 0.9187 0.9187
0.0603 0.3311 0.3256
0.0068 0.3157 0.3086
0.0068 0.6644 0.6644
0.0283 0.3385 0.6275
0.0253 0.5179 0.5179

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_43470 (Brugia malayi), Hypothetical 112.3 kDa protein K02A2.3 in chromosome II
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