Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.0397 | 1 | 1 |
Leishmania major | squalene synthase, putative | 0.0303 | 0.7287 | 0.8281 |
Trypanosoma cruzi | squalene synthase, putative | 0.0303 | 0.7287 | 0.8545 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0182 | 0.3831 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0346 | 0.8528 | 1 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0094 | 0.1311 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1311 | 0.2522 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.4389 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0303 | 0.7287 | 0.8545 |
Echinococcus multilocularis | geminin | 0.0202 | 0.4389 | 0.3542 |
Trypanosoma cruzi | phytoene synthase, putative | 0.0094 | 0.1311 | 0.1537 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0164 | 0.3301 | 0.3871 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0164 | 0.3301 | 0.2758 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0059 | 0.0305 | 0.0358 |
Trypanosoma brucei | squalene synthase, putative | 0.0303 | 0.7287 | 0.8545 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0137 | 0.2527 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0346 | 0.8528 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0164 | 0.3301 | 0.3871 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.4389 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1311 | 0.4605 |
Mycobacterium ulcerans | hypothetical protein | 0.0182 | 0.3831 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0346 | 0.8528 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0137 | 0.2527 | 1 |
Echinococcus granulosus | geminin | 0.0202 | 0.4389 | 0.3542 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0346 | 0.8528 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0137 | 0.2527 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0056 | 0.0205 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 135 uM | Inhibition of squalene synthase in rat liver microsomes assessed as [3H] FPP to squalene conversion level after 10 mins by scintillation counting | ChEMBL. | 20888243 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.