Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0265 | 0.0591 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0265 | 0.0265 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0265 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0311 | 0.4484 | 0.9996 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0265 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0311 | 0.4486 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0689 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0311 | 0.4486 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0311 | 0.4484 | 0.9996 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0311 | 0.4486 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0265 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0265 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0265 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0265 | 1 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0689 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0265 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0265 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0265 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0311 | 0.4486 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0265 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0265 | 0.0265 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0265 | 0.0591 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0265 | 0.0591 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0265 | 1 |
Onchocerca volvulus | Putative neutral sphingomyelinase | 0.0005 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0265 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0265 | 0.0265 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0265 | 1 |
Onchocerca volvulus | 0.0005 | 0 | 0.5 | |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0265 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0265 | 0.0265 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0311 | 0.4486 | 0.4486 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.