Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acyl-CoA desaturase 1 | Starlite/ChEMBL | References |
Homo sapiens | stearoyl-CoA desaturase 5 | Starlite/ChEMBL | References |
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0309 | 1 | 0.5 | |
Echinococcus multilocularis | insulin receptor | 0.0142 | 0.321 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0124 | 0.2474 | 0.7675 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2474 | 0.2861 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0047 | 0.0146 |
Leishmania major | fatty-acid desaturase, putative | 0.0309 | 1 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0079 | 0.0617 | 0.0672 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.057 | 0.0617 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0273 | 0.8531 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0142 | 0.321 | 1 |
Onchocerca volvulus | 0.0309 | 1 | 0.5 | |
Echinococcus multilocularis | serotonin receptor | 0.0124 | 0.2474 | 0.7675 |
Brugia malayi | Protein kinase domain containing protein | 0.0142 | 0.321 | 0.3728 |
Echinococcus granulosus | insulin receptor | 0.0142 | 0.321 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2474 | 0.2861 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0047 | 0.0146 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0142 | 0.321 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0142 | 0.321 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0047 | 0.0146 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0142 | 0.321 | 0.3728 |
Brugia malayi | acyl-CoA desaturase | 0.0273 | 0.8531 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0124 | 0.2474 | 0.7675 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0142 | 0.321 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0273 | 0.8531 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0309 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0273 | 0.8531 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0309 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0124 | 0.2474 | 0.7709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.