Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0227 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0227 | 0 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0964 | 0.2791 | 0.2791 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2866 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0964 | 0.2791 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0227 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0964 | 0.2791 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0227 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0227 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0964 | 0.2791 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0227 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0964 | 0.2791 | 1 |
Plasmodium falciparum | peptidase, putative | 0.0227 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0227 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2866 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0227 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0964 | 0.2791 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0964 | 0.2791 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2866 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2866 | 1 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0227 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0227 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0227 | 0 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0964 | 0.2791 | 1 |
Brugia malayi | hypothetical protein | 0.0736 | 0.193 | 0.193 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0227 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0227 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0227 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0736 | 0.193 | 0.193 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0227 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0964 | 0.2791 | 0.2791 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2866 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0964 | 0.2791 | 0.2791 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0227 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 34.67 uM | Cytotoxicity against human BxPC3 cells expressing COX2 after 24 hrs by MTT assay | ChEMBL. | 20729081 |
IC50 (functional) | = 56.65 uM | Cytotoxicity against human estrogen receptor-deficient BT20 cells after 24 hrs by MTT assay | ChEMBL. | 20729081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.