Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0817 | 0.4136 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.1746 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.122 | 0.6683 | 0.6387 |
Toxoplasma gondii | perforin-like protein PLP1 | 0.0162 | 0 | 0.5 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.0309 | 0.093 | 0.5 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.0309 | 0.093 | 0.0121 |
Onchocerca volvulus | 0.0309 | 0.093 | 1 | |
Onchocerca volvulus | 0.0292 | 0.0819 | 0.8614 | |
Echinococcus multilocularis | macrophage expressed protein | 0.1466 | 0.8237 | 0.8079 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0292 | 0.0819 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0819 | 0.1723 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.0819 | 0.1723 |
Echinococcus multilocularis | translocator protein | 0.0309 | 0.093 | 0.0121 |
Echinococcus granulosus | acetylcholinesterase | 0.0817 | 0.4136 | 0.3613 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0817 | 0.4136 | 0.3613 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.093 | 0.2 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0817 | 0.4136 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0817 | 0.4136 | 0.3613 |
Brugia malayi | Doublecortin family protein | 0.0292 | 0.0819 | 0.1723 |
Loa Loa (eye worm) | carboxylesterase | 0.0817 | 0.4136 | 1 |
Toxoplasma gondii | MAC/Perforin domain-containing protein | 0.0162 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0817 | 0.4136 | 1 |
Echinococcus granulosus | translocator protein | 0.0309 | 0.093 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.1466 | 0.8237 | 0.8079 |
Echinococcus multilocularis | acetylcholinesterase | 0.0817 | 0.4136 | 0.3613 |
Onchocerca volvulus | 0.0309 | 0.093 | 1 | |
Brugia malayi | hypothetical protein | 0.0292 | 0.0819 | 0.1723 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.093 | 0.2 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.093 | 0.2 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.093 | 0.2 |
Onchocerca volvulus | 0.0292 | 0.0819 | 0.8614 | |
Plasmodium falciparum | LCCL domain-containing protein | 0.0292 | 0.0819 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0817 | 0.4136 | 0.3613 |
Onchocerca volvulus | 0.0309 | 0.093 | 1 | |
Chlamydia trachomatis | hypothetical protein | 0.0162 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.1746 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0817 | 0.4136 | 0.3613 |
Echinococcus granulosus | macrophage expressed protein | 0.1466 | 0.8237 | 0.8079 |
Brugia malayi | TspO/MBR family protein | 0.0309 | 0.093 | 0.2 |
Loa Loa (eye worm) | hypothetical protein | 0.0817 | 0.4136 | 1 |
Onchocerca volvulus | 0.0309 | 0.093 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0817 | 0.4136 | 0.3613 |
Brugia malayi | Carboxylesterase family protein | 0.0817 | 0.4136 | 1 |
Brugia malayi | hypothetical protein | 0.0292 | 0.0819 | 0.1723 |
Loa Loa (eye worm) | doublecortin family protein | 0.0292 | 0.0819 | 0.1723 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 54.537 uM | PUBCHEM_BIOASSAY: TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.