Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0029 | 0.8634 | 0.8159 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0029 | 0.8634 | 0.8159 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0014 | 0.3107 | 0.0713 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0012 | 0.2578 | 0.8298 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.3107 | 0.0713 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.002 | 0.5403 | 0.4294 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0016 | 0.3945 | 0.2485 |
Leishmania major | p450 reductase, putative | 0.0032 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0016 | 0.3945 | 0.8981 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0029 | 0.8634 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0012 | 0.2578 | 0.8298 |
Echinococcus multilocularis | bloom syndrome protein | 0.0026 | 0.7577 | 0.6993 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.002 | 0.5403 | 0.4294 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0012 | 0.2578 | 0.5 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0012 | 0.2578 | 0.079 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0012 | 0.2578 | 0.8298 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0012 | 0.2578 | 0.079 |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.5403 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.3107 | 0.0713 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0012 | 0.2578 | 0.079 |
Echinococcus granulosus | bloom syndrome protein | 0.0026 | 0.7577 | 0.6993 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.5403 | 0.4294 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.3107 | 0.0713 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.1942 | 0.4422 |
Echinococcus multilocularis | methionine synthase reductase | 0.002 | 0.5403 | 0.4294 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.6411 | 0.5547 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0026 | 0.7577 | 0.6993 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0026 | 0.7577 | 0.6993 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.5558 | 0.4487 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0012 | 0.2578 | 0.8298 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0016 | 0.3945 | 0.8981 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5635 | 0.4582 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.4469 | 0.2548 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.3107 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0016 | 0.4036 | 0.2599 |
Giardia lamblia | Hypothetical protein | 0.0029 | 0.8634 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.002 | 0.5403 | 0.4294 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0026 | 0.7577 | 0.6735 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0012 | 0.2578 | 0.8298 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0026 | 0.7577 | 0.6735 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.4392 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0012 | 0.2578 | 0.079 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0029 | 0.8634 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.1942 | 0.4422 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.