Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 1068 aa | 927 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.004 | 0.0112 | 0.5 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0222 | 0.1841 | 0.2756 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.0856 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.004 | 0.0112 | 0.0426 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0606 | 0.5464 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0081 | 0.0506 | 0.5294 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0081 | 0.0506 | 0.5294 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0118 | 0.0856 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0077 | 0.0462 | 0.0354 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0222 | 0.1841 | 0.1748 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.0856 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0118 | 0.0856 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0052 | 0.0234 | 0.0227 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.1086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0132 | 0.0053 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.0628 | 0.0963 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0606 | 0.5464 | 1 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0104 | 0.0723 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0462 | 0.0386 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0115 | 0.0823 | 0.1328 |
Entamoeba histolytica | protein kinase, putative | 0.0606 | 0.5464 | 1 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0222 | 0.1841 | 0.2756 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0094 | 0.0628 | 0.0963 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0118 | 0.0856 | 0.0752 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0606 | 0.5461 | 0.9995 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0118 | 0.0856 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0198 | 0.1612 | 0.1545 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0118 | 0.0856 | 0.139 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0057 | 0.0278 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1086 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0606 | 0.5464 | 0.5412 |
Entamoeba histolytica | protein kinase, putative | 0.0606 | 0.5464 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0606 | 0.5461 | 0.9995 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.37 uM | Inhibition of PI3Kalpha | ChEMBL. | 20822905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.