TDR Targets

Basic information

Technical information

TDR Targets ID: 1258436
Name: (5-formyl-2-methoxyphenyl) morpholine-4-carbo xylate
MW: 265.262 | Formula: C13H15NO5
H donors: 0 H acceptors: 2 LogP: 0.75 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1OC(=O)N1CCOCC1)C=O
InChi: 1S/C13H15NO5/c1-17-11-3-2-10(9-15)8-12(11)19-13(16)14-4-6-18-7-5-14/h2-3,8-9H,4-7H2,1H3
InChiKey: NRVUFSWVIXWMBG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5-formyl-2-methoxy-phenyl) morpholine-4-carboxylate
4-morpholinecarboxylic acid (5-formyl-2-methoxyphenyl) ester
morpholine-4-carboxylic acid (5-formyl-2-methoxy-phenyl) ester
(5-methanoyl-2-methoxy-phenyl) morpholine-4-carboxylate
ZINC00035115
A2516/0106917
Morpholine-4-carboxylic acid, 3-formyl-6-methoxyphenyl ester
AG-205/40650357
Oprea1_120752

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0332	0.0345
Brugia malayi	beta-lactamase family protein	0.0036	0.0332	0.063
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0225	0.0071
Loa Loa (eye worm)	TAR-binding protein	0.0128	0.3017	0.5599
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0922	0.0804
Brugia malayi	Heterochromatin protein 1	0.0141	0.3388	0.6434
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0332	0.063
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0225	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0922	0.0804
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0379	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0332	0.0345
Echinococcus multilocularis	geminin	0.0343	0.9243	0.9231
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.7678	1
Echinococcus granulosus	chromobox protein 1	0.0141	0.3388	0.3305
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0085	0.1765	0.249
Echinococcus multilocularis	tar DNA binding protein	0.0128	0.3017	0.2907
Brugia malayi	chromobox protein homolog 3	0.0079	0.1591	0.3022
Schistosoma mansoni	chromobox protein	0.0141	0.3388	0.3557
Schistosoma mansoni	kinase	0.005	0.074	0.0644
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.7678	1
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0.1591	0.1715
Schistosoma mansoni	hypothetical protein	0.0032	0.0225	0.0077
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0141	0.3392	0.5503
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1096	0.1841
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0703	0.0505
Echinococcus granulosus	tar DNA binding protein	0.0128	0.3017	0.2929
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2134	0.2454
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0225	0.0427
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0379	0.0228
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2134	0.2454
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0141	0.3392	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0332	0.021
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.5266	1
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0332	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.7678	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0225	0.0137
Brugia malayi	TAR-binding protein	0.0128	0.3017	0.5729
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.2134	0.2178
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0225	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0332	0.0345
Echinococcus multilocularis	chromobox protein 1	0.0141	0.3388	0.3284
Trichomonas vaginalis	chromobox protein, putative	0.0141	0.3388	0.416
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0155	0.0032
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.3017	0.3149
Trypanosoma brucei	polo-like protein kinase	0.0098	0.2134	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0289	0.7678	1
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0098	0.2134	1
Trichomonas vaginalis	conserved hypothetical protein	0.0079	0.1591	0.1715
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0332	0.0345
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0332	0.0194
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2134	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1591	0.281
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2134	0.2454
Brugia malayi	Pre-SET motif family protein	0.003	0.0155	0.0295
Schistosoma mansoni	hypothetical protein	0.0032	0.0225	0.0077
Trichomonas vaginalis	chromobox protein, putative	0.0085	0.1765	0.1951
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.1299	0.2467
Schistosoma mansoni	hypothetical protein	0.0037	0.0379	0.0247
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.2225	0.4225
Trichomonas vaginalis	chromobox protein, putative	0.0141	0.3388	0.416
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0098	0.2134	0.2036
Loa Loa (eye worm)	heterochromatin protein 1	0.0141	0.3388	0.6325
Echinococcus granulosus	geminin	0.0343	0.9243	0.9233
Brugia malayi	RNA binding protein	0.0128	0.3017	0.5729
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.7678	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0332	0.063
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2225	0.405
Toxoplasma gondii	ABC1 family protein	0.0036	0.0332	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0053	0.0824	0.0736
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0225	0.0427
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.3017	0.3149
Schistosoma mansoni	chromobox protein	0.0141	0.3388	0.3557
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2134	0.2454
Schistosoma mansoni	hypothetical protein	0.0343	0.9243	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0098	0.2134	0.3131
Brugia malayi	hypothetical protein	0.0037	0.0379	0.072
Brugia malayi	serine/threonine-protein kinase plk-2	0.0098	0.2134	0.4053
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2134	0.2454
Loa Loa (eye worm)	RNA binding protein	0.0128	0.3017	0.5599
Onchocerca volvulus		0.0235	0.609	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0289	0.7678	0.5
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0098	0.2134	0.201
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0332	0.0194
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0332	0.0345
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0079	0.1591	0.2187
Schistosoma mansoni	hypothetical protein	0.0032	0.0225	0.0077
Echinococcus granulosus	chromobox protein 1	0.0141	0.3388	0.3305
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.2134	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0098	0.2134	0.2405
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.7678	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0289	0.7678	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.5894	1
Onchocerca volvulus		0.0062	0.1096	0.1328
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0703	0.0505
Brugia malayi	hypothetical protein	0.0157	0.3835	0.7282
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1299	0.2238
Trichomonas vaginalis	chromobox protein, putative	0.0085	0.1765	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0332	0.0345
Onchocerca volvulus		0.0053	0.0824	0.0856
Brugia malayi	RNA recognition motif domain containing protein	0.0128	0.3017	0.5729
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.3017	0.3149
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.7678	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0128	0.3017	0.5599
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0225	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0332	0.0345
Brugia malayi	beta-lactamase	0.0036	0.0332	0.063
Echinococcus granulosus	GPCR family 2	0.0032	0.0225	0.0103
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.609	0.7838
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.7678	1
Loa Loa (eye worm)	hypothetical protein	0.0157	0.3835	0.72
Onchocerca volvulus		0.0157	0.3835	0.6083
Schistosoma mansoni	hypothetical protein	0.0343	0.9243	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0225	0.0137
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2134	0.2454
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0225	0.0071
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.3017	0.3149
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.2225	0.405
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0098	0.2134	0.3873
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0379	0.0259
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0141	0.3392	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0332	0.0345
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0289	0.7678	1
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.3017	0.3149
Schistosoma mansoni	hypothetical protein	0.0069	0.1299	0.1259
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.2134	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0332	0.0179
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.2225	0.4225
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0289	0.7678	1
Echinococcus multilocularis	expressed protein	0.037	1	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0225	0.0077
Brugia malayi	Pre-SET motif family protein	0.0206	0.5266	1
Echinococcus multilocularis	chromobox protein 1	0.0141	0.3388	0.3284

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.2753 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1340932

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1258436