Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0062 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0062 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0627 | 0.1402 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0627 | 0.1402 |
Schistosoma mansoni | hypothetical protein | 0.1019 | 0.4091 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0062 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.1019 | 0.4091 | 0.5 |
Echinococcus granulosus | Transglutaminase | 0.1019 | 0.4091 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0062 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.0627 | 0.1402 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Mycobacterium ulcerans | transglutaminase family protein | 0.1019 | 0.4091 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0062 | 0.0151 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.1019 | 0.4091 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Mycobacterium tuberculosis | Long conserved protein | 0.1019 | 0.4091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0059 | 0.9606 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Brugia malayi | Thioredoxin family protein | 0.1019 | 0.4091 | 1 |
Echinococcus multilocularis | Transglutaminase | 0.1019 | 0.4091 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Giardia lamblia | Transglutaminase/protease, putative | 0.1019 | 0.4091 | 0.5 |
Echinococcus multilocularis | geminin | 0.0171 | 0.0627 | 0.1402 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.1019 | 0.4091 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1019 | 0.4091 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.1216 uM | PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.