Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | ORL1-like opioid receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | follicle stimulating hormone receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Dopamine receptor protein 2 | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Serotonin receptor | 0.0018 | 0.0266 | 0.0266 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | G protein-coupled receptor | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | larval opioid receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9606 | 0.9606 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | G-protein coupled receptor | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Dopamine receptor protein 1 | 0.0018 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0033 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | sulfakinin receptor protein | 0.0018 | 0.0266 | 0.0266 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | putative neuropeptide receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | neuropeptide F receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Dopamine receptor | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | AKH receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Serotonin receptor | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Melatonin receptor type 1A | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0033 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | neuropeptide F receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | GnHR receptor homolog | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | G-protein coupled receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0266 | 0.0266 |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Brugia malayi | RE15519p | 0.0018 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0018 | 0.0266 | 0.0266 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0112 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.