Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | checkpoint kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Schistosoma japonicum | Serine/threonine-protein kinase Chk1, putative | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | Get druggable targets OG5_130454 | All targets in OG5_130454 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0043 | 0.0168 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.01 | 0.0641 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.1714 | 0.2 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0256 | 0.1936 | 0.226 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1227 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.1492 | 0.1575 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0043 | 0.0168 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0256 | 0.1936 | 0.1798 |
Schistosoma mansoni | alpha-l-fucosidase | 0.1055 | 0.8569 | 1 |
Giardia lamblia | Methionine aminopeptidase | 0.0043 | 0.0168 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0202 | 0.1492 | 0.1741 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0043 | 0.0168 | 0.5 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.1055 | 0.8569 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0256 | 0.1936 | 0.1798 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.01 | 0.0641 | 1 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0043 | 0.0168 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0043 | 0.0168 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0202 | 0.1492 | 0.1741 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0463 | 0.3655 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.01 | 0.0641 | 1 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0043 | 0.0168 | 0.0196 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0463 | 0.3655 | 1 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0043 | 0.0168 | 0.5 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0256 | 0.1936 | 0.226 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.1714 | 0.2 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0256 | 0.1936 | 0.2105 |
Brugia malayi | initiation factor 2-associated protein. | 0.0043 | 0.0168 | 0.0196 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.1055 | 0.8569 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1227 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 nM | Inhibition of His-tagged CHK1 after 2 hrs by liquid scintillation counting | ChEMBL. | 21074424 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.