Detailed view for LOAG_04875

Basic information

TDR Targets ID: 947986
Loa Loa (eye worm), alpha-L-fucosidase
Source Database / ID:  KEGG  

pI: 8.8603 | Length (AA): 493 | MW (Da): 57871 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01120   Alpha-L-fucosidase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004560   alpha-L-fucosidase activity  
GO:0005975   carbohydrate metabolic process  
GO:0006004   fucose metabolic process  

Metabolic Pathways

Other glycan degradation (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
49 466 1hl9 (A) 8 445 25.00 0 1 0.84327 0.48
49 361 1hl9 (A) 8 361 35.00 0 1 0.818188 0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129683)

Species Accession Gene Product
Brugia malayi Bm1_37265   Alpha-L-fucosidase family protein
Caenorhabditis elegans CELE_W03G11.3   Protein W03G11.3
Dictyostelium discoideum DDB_G0274391   hypothetical protein
Dictyostelium discoideum DDB_G0276661   hypothetical protein
Drosophila melanogaster Dmel_CG6128   alpha-L-fucosidase
Echinococcus granulosus EgrG_000618900   fucosidase alpha L 1 tissue
Echinococcus multilocularis EmuJ_000618900   fucosidase, alpha L 1, tissue
Homo sapiens ENSG00000001036   fucosidase, alpha-L- 2, plasma
Homo sapiens ENSG00000179163   fucosidase, alpha-L- 1, tissue
Loa Loa (eye worm) LOAG_04875   alpha-L-fucosidase
Mus musculus ENSMUSG00000028673   fucosidase, alpha-L- 1, tissue
Mus musculus 66848   fucosidase, alpha-L- 2, plasma
Mycobacterium ulcerans MUL_2911   alpha-L-fucosidase
Schistosoma japonicum Sjp_0201950   ko:K01206 alpha-L-fucosidase [EC3.2.1.51], putative
Schistosoma mansoni Smp_146250   alpha-l-fucosidase
Schmidtea mediterranea mk4.010223.00  
Schmidtea mediterranea mk4.002271.05   Tissue alpha-L-fucosidase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fucosidase, alpha-L- 1, tissue Compounds References
Homo sapiens fucosidase, alpha-L- 2, plasma Compounds References
Bos taurus Alpha-L-fucosidase 1 Compounds References
Rattus norvegicus Alpha-L-fucosidase I Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0761 1 1
0.0515 0.2949 0.4503
0.1865 0.5842 1
0.1306 0.3534 0.3524
0.4727 0.4044 0.4043
0.225 0.3691 0.3691
0.0522 0.3765 0.4812
0.2931 0.717 0.717
0.0383 1 1
0.0169 0.3177 0.3177
0.0423 0.3276 0.3276
0.0509 0.4586 0.4586
0.0414 0.2579 0.2579
0.6015 0.5394 0.539
0.0515 0.2949 0.4503
0.0394 0.4401 0.4254
0.0289 0.2699 0.2671
0.1563 0.2703 0.4385
0.0819 0.4619 0
0.0469 1 1
0.1396 0.5648 1
0.5762 0.5445 0.5445
0.144 0.3848 0.3848
0.6775 0.5118 0.5117
0.6476 0.5665 0.5664
0.271 0.5317 0.5896
0.4088 0.4038 0.4038
0.2931 0.717 0.717
0.0522 0.3765 0.4812
0.5666 0.543 0.543
0.0469 1 1
0.9801 0.8592 1
0.1257 0.4041 0.4041
0.1 0.4683 0.4682
0.8606 0.8593 1
0.1563 0.2705 0.4388
0.4618 0.4654 0.4652
0.0322 0.3977 0.3977
0.0569 0.4257 0.4204
0.0833 0.5899 0.7761
0.1905 0.7892 1
0.6404 0.5639 0.5639
0.0792 0.5771 1
0.0322 0.3977 0.3977
0.0459 0.2974 0.2764
0.0262 0.3923 0.5962
0.025 0.3048 1
0.0387 0.4869 1
0.0522 0.3765 0.4812
0.0919 0.7221 0.9361
0.0913 0.8577 1
0.4618 0.4654 0.4652
0.0834 0.6591 0.6583
0.0256 0.3576 0.3572
0.0808 0.5516 1
0.0193 0.2609 0.2722
0.0313 0.5896 0.8032
0.4727 0.4044 0.4043
0.0414 0.3427 0.3296
0.1399 0.2807 0.2806
0.0322 0.3665 0.3971
1.519 0.2884 0.8535
0.3681 0.3729 0.3729
0.0528 0.5021 1
0.6185 0.5856 0.5856
0.0293 0.5355 1
0.1016 0.8583 1
1.6312 0.8165 1
0.1306 0.2933 0.2926
0.1147 0.6024 0.6024
0.0552 0.5997 0.7697
0.0778 0.5911 0.6342
0.0419 1 1
0.0832 0.3427 0.3427
0.5099 0.4018 0.4018
0.7156 0.6195 0.6195
0.4932 0.8029 1
0.5077 0.4132 0.4132
0.058 0.5297 1
0.6603 0.8564 1
0.0771 0.4016 0.6501
0.134 0.4084 0.4084
0.3887 0.4137 0.4137
0.0779 0.5773 0.9638
0.6108 0.5134 0.5134
0.1822 0.3003 0.3003
0.7199 0.6162 0.6162
0.0233 0.2592 0.2496
0.5038 0.4525 0.4525
0.6754 0.5623 0.5623
0.1436 0.4619 0.5
0.0519 0.4576 0.4576
0.1088 0.3884 0.3884
0.684 0.4789 0.4789
0.0832 0.3427 0.3427
0.1822 0.3003 0.3003
0.6787 0.519 0.519
0.3185 0.5994 1
0.0519 0.5474 0.5821
0.1165 0.489 0.4881
0.1822 0.3003 0.3003
0.0832 0.3427 0.3427
0.2544 0.5559 0.5559
0.2635 0.3571 0.3571
0.0313 0.3588 0.8374
0.5173 0.7745 0.5
0.0832 0.3427 0.3427
0.7571 0.5758 0.6473
0.0673 0.6393 0.6352
0.0469 1 1
0.0832 0.3427 0.3427
0.0856 0.6287 0.6287
0.0383 0.8036 0.7981
0.038 0.3607 0.8033
0.4263 0.4933 0.4933
0.5098 0.41 0.41
0.029 0.323 1
0.4647 0.4089 0.4089
0.0792 0.5771 1
0.0519 0.4576 0.4576
0.018 0.3178 1
0.018 0.3178 1
0.4576 0.8197 1
0.0519 0.3538 0.3538
0.0252 0.4619 0.5
0.0761 0.5902 1
0.6545 0.5613 0.5613
1.8296 0.6774 0.829
0.0313 0.4125 1
0.2024 0.4374 0.5146
0.4088 0.4038 0.4038
0.125 0.5931 0.8969
0.3887 0.4137 0.4137
0.1147 0.6024 0.6024
0.0513 0.6019 1
0.5033 0.4099 0.4099
0.0258 0.3201 1
0.9863 0.8592 1
0.5431 0.5592 0.5591
0.4932 0.8029 1
0.1398 0.3585 0.3585
0.5762 0.5445 0.5445
0.7156 0.6195 0.6195
0.1822 0.3003 0.3003
0.4683 0.4176 0.4176
0.129 0.7922 0.8948
0.0193 0.2609 0.2722
0.0567 0.5288 1
0.2797 0.3075 0.3075
0.0519 0.3538 0.3538
0.1937 0.2512 0.2512
1.2606 0.7745 0.5
0.6545 0.5613 0.5613
0.0575 0.573 1
0.1006 0.8576 1
0.43 0.4111 0.4111
0.0389 0.8036 0.7981
0.7571 0.5758 0.6473
0.3693 0.6829 0.6829
0.0832 0.3427 0.3427
0.0322 0.3671 0.3975
1.6034 0.8149 1
0.0541 0.3328 0
0.0792 0.5771 1
0.0515 0.6019 1
0.6476 0.5665 0.5664
0.1937 0.3833 0.4996
0.0515 0.2949 0.4503
0.0552 0.5997 0.7697
0.1174 0.8578 0.8801
0.4727 0.4044 0.4043
0.6854 0.6253 0.6252
0.6155 0.5193 0.5191
0.0985 0.4076 0.4076
0.6476 0.5665 0.5664
0.0819 0.4619 0
0.1338 0.5548 0.5548
0.1 0.8568 1
1.8296 0.6774 0.829
0.1937 0.3833 0.4996
0.271 0.2617 0.5898
0.3887 0.4137 0.4137
0.0832 0.3427 0.3427
0.0313 0.4619 0.5724
0.6687 0.5275 0.5275
0.2635 0.3571 0.3571
0.4932 0.8029 1
0.0527 0.4003 0.4003
0.0469 1 0.5
0.4037 0.5545 0.5545
0.0322 0.3665 0.3971
0.0845 0.6195 0.6195
0.684 0.4789 0.4789
0.0856 0.6346 0.6313
0.332 0.6498 0.6496
0.0293 0.352 0.352
0.1937 0.2512 0.2512
0.7084 0.5787 0.5787
0.5431 0.5592 0.5591
0.125 0.8572 1
0.0769 0.5838 0.9639
0.5689 0.5339 0.5339
0.3887 0.4137 0.4137
0.4262 0.6239 0.6239
0.5939 0.5645 0.5644
0.1546 0.4079 0.4072
0.0313 0.591 1
0.0762 1 1
0.6223 0.5499 0.5498
0.0313 0.5965 1
0.1035 0.8545 1
0.1272 0.4091 1
0.0792 0.5771 1
0.0389 0.2998 1
1.8031 0.8165 1
0.1039 0.3472 0.3472
0.0387 0.4869 1
0.125 0.5931 0.8969
0.0376 0.2949 1
0.032 0.61 0.6099
0.6687 0.5206 0.5206
0.0832 0.3427 0.3427
0.0833 0.5899 0.7761
0.0779 0.5773 0.9638
0.1563 0.2701 0.4383
0.2835 0.5771 0.577
0.079 0.6433 0.6412
0.1822 0.3003 0.3003
0.6053 0.5425 0.5425
0.6108 0.5134 0.5134
0.0538 0.4823 0.4823
0.0313 0.3792 0.5
0.0776 0.5699 0.6481
0.1021 0.7886 0.7886
0.0578 0.261 0.445
0.0785 0.6004 1
0.032 0.61 0.6099
1.519 0.2884 0.8535
0.241 0.2811 0.2811
0.1007 0.8572 1
0.1822 0.3003 0.3003
0.0379 0.2728 0.8162
0.1 0.6625 0.6624
0.6476 0.5665 0.5664
0.1006 0.3228 0.6769
0.0541 0.6002 0.6758
0.216 0.6007 1
0.0519 0.3538 0.3538
0.1019 0.8568 1
0.0833 0.2834 0.2834
0.0816 0.5561 1
0.1333 0.6724 0.6724
0.1937 0.3833 0.4996
0.0857 1 1
0.3887 0.4137 0.4137
0.0469 1 1
0.9863 0.8592 1
0.0313 0.4619 0.5724
0.0569 0.4257 0.4204
0.0536 0.4619 1
0.0285 0.2565 0.2565
0.4156 0.2569 0.2568
0.0469 0.2804 1
0.1822 0.3003 0.3003
0.1338 0.5548 0.5548
0.1055 0.8569 1
0.0832 0.3427 0.3427
0.4427 0.3991 0.3991
0.4075 0.4503 0.4502
0.0519 0.3538 0.3538
0.1563 0.2705 0.4388
0.0469 1 1
0.0552 0.5997 0.7697
0.0552 0.5997 0.7697
0.6691 0.5324 0.5324
0.0804 0.5984 1
0.028 0.4419 0.4415
0.1937 0.3833 0.4996
0.0547 0.4619 0.4483
0.6336 0.5623 0.5623
0.1937 0.3833 0.4996
0.0377 0.4409 0.44
0.085 0.3557 0.6212
0.0519 0.3538 0.3538
0.125 0.5931 0.8969
0.1396 0.5648 1
0.2859 0.7642 0.7796
0.4932 0.8029 1
0.0823 1 1
0.1822 0.3003 0.3003
0.0381 0.4599 0.4599
0.4608 0.8206 1
0.0322 0.3665 0.3971
0.125 0.5931 0.8969
0.2635 0.3571 0.3571
0.028 0.4419 0.4415
0.6733 0.5279 0.5279
0.3887 0.4137 0.4137
0.0313 0.5933 1
0.125 0.5931 0.8969
0.2278 0.8123 1
0.1086 0.5781 0.5776
0.295 0.2837 0.2837
0.1937 0.3833 0.4996
0.0289 0.2699 0.2671
0.1249 0.5883 0.6175
0.1008 0.8586 1
0.0333 0.61 0.6099
0.0515 0.2949 0.4503
0.1822 0.3003 0.3003
0.6046 0.5444 0.5444
0.0469 0.2804 1
0.2859 0.7642 0.7796
0.2295 0.854 0.5
0.0383 0.2732 0.2671
0.125 0.8579 1
0.1021 0.7504 0.7504
0.1937 0.3833 0.4996
0.0318 0.5171 1
0.6369 0.5725 0.5725
0.2846 0.4913 0.4913
0.0794 0.5933 0.5933
0.2797 0.3075 0.3075
0.1147 0.6024 0.6024
0.0313 0.4274 1
0.6313 0.5181 0.5181
0.4075 0.4503 0.4502
0.0578 0.261 0.445
0.0567 0.4187 0.4187
0.4968 0.4417 0.4417
0.0469 1 1
0.2703 0.4413 0.4413
1.361 0.8342 1
0.0379 0.2728 0.8162
0.197 0.414 0.414
1.7718 0.8216 1
0.125 0.8583 1
0.2299 0.7174 0.7174
0.0882 0.5204 0.7242
0.5033 0.4099 0.4099
0.4618 0.4654 0.4652
0.1925 0.3554 0.3554
0.1257 0.4041 0.4041
0.1937 0.3833 0.4996
0.9863 0.8592 1
0.1249 0.5883 0.6175
0.0252 0.2513 0.2948
0.1937 0.3833 0.4996
0.1488 0.3814 0.3814
0.0313 0.4242 0.5
0.1032 0.8536 1
0.3693 0.6829 0.6829
0.3185 0.6001 0.5988
0.5077 0.4132 0.4132
0.0762 1 1
0.0488 0.4916 1
0.0784 0.9531 1
0.4342 0.5599 0.5598
0.1937 0.3833 0.4996
0.5282 0.563 0.563
0.088 0.521 0.909
0.6775 0.5118 0.5117
0.2024 0.4374 0.5146
0.0254 0.471 1
0.0255 0.43 0.43
0.4727 0.4044 0.4043
0.0383 0.2732 0.2671
0.2295 0.7745 0.5
0.0313 0.6005 1
0.568 0.514 0.514
0.0836 0.4186 1
0.0848 0.5124 0.7057
0.6336 0.5623 0.5623
0.9865 0.8588 1
0.0761 0.5902 1
0.0253 0.5252 1
0.125 0.5931 0.8969
0.0313 0.3792 0.5
0.6457 0.5136 0.5135
0.0832 0.3427 0.3427
0.5278 0.4825 0.4824
0.1659 0.6019 1
0.1379 0.5109 0.5109
0.0821 0.618 0.618
0.0799 0.6443 0.6443
0.3887 0.4137 0.4137
0.219 0.455 0.4548
0.3887 0.4137 0.4137
0.0794 0.5829 0.5829
0.3887 0.4137 0.4137
0.0599 0.4125 1
0.0387 0.4869 1
0.1398 0.3585 0.3585
0.1 0.4061 0.4061
0.0785 0.6004 1
0.6059 0.5197 0.5197
0.018 0.3177 1
0.1822 0.3003 0.3003
0.0869 0.2708 0.2722
0.125 0.8586 1
0.1 0.835 1
0.0387 0.4869 1
0.0549 0.4822 0.2328
0.0846 0.6292 0.6292
0.6447 0.5613 0.5613
0.4986 0.4126 0.4126
0.1399 0.2807 0.2806
0.0599 0.4125 1
0.1822 0.3003 0.3003
1.1057 0.8594 1
0.0854 0.5979 1
0.0394 0.4401 0.4254
0.6336 0.5623 0.5623
0.0869 0.2708 0.2722
0.0632 0.3071 0.3071
0.6513 0.5521 0.5519
1.519 0.2884 0.8535
0.1822 0.3003 0.3003
0.0414 0.2579 0.2579
0.0294 0.274 0
0.6074 0.5587 0.5587
0.6336 0.5623 0.5623
0.08 0.2605 0.26
0.1563 0.2701 0.4383
0.2335 0.7745 0.5
0.1016 0.3888 0.3888
0.0803 0.5865 1
0.4655 0.4064 0.4064
0.6787 0.519 0.519
0.1386 0.7871 0.8382
0.0833 0.2834 0.2834
0.1563 0.2701 0.4383
0.197 0.4138 0.4138
0.0856 0.6384 0.6384
0.9801 0.8592 1
0.0377 0.64 0.64
0.0797 0.6549 0.648
0.5431 0.5592 0.5591
0.0514 0.5751 0.6803
0.0833 0.2834 0.2834
0.3887 0.4137 0.4137
0.0809 0.6282 0.6282
0.0746 0.2535 0.4033
0.7195 0.5916 0.5916
0.1344 0.7905 0.8341
0.057 0.7769 0.9772
0.3887 0.4137 0.4137
0.1344 0.7905 0.8341
0.1023 0.3678 0.3678
1.6312 0.8166 1
0.1 0.4683 0.4682
0.4088 0.4038 0.4038
0.3887 0.4137 0.4137
0.0469 0.2804 1
0.038 0.2769 1
0.1399 0.2807 0.2806
0.0383 1 1
0.0255 0.43 0.43
0.67 0.5434 0.5434
1.0082 0.8588 1
0.0761 0.5938 1
1.8296 0.6774 0.829
0.0402 0.5754 1
0.6713 0.4748 0.4748
0.0784 0.9645 0.9645
0.051 0.3359 0
0.0866 1 1
0.7569 0.7745 0.5
0.4647 0.4089 0.4089
0.4608 0.2676 0.2675
1.7327 0.2911 0.5517
0.0273 0.3778 0.3778
0.1546 0.4079 0.4072
0.0262 0.5874 1
0.1937 0.3833 0.4996
0.0333 0.61 0.6099
0.0869 0.2708 0.2722
0.6473 0.5514 0.5514
0.469 0.4143 0.4143
0.1338 0.5548 0.5548
0.1004 0.3834 0.3834
0.2177 0.5872 1
0.0251 0.4619 0.5
0.6749 0.5476 0.5476
0.8606 0.8593 1
0.1008 0.8584 1
0.1937 0.3833 0.4996
0.6027 0.5767 0.5767
0.0795 0.3927 0.6508
0.0258 0.5643 1
0.6409 0.6607 0.6607
0.0822 0.6126 0.6126
0.3498 0.6021 0.6586
0.0911 0.4755 0.4725
0.4679 0.5764 0.5764
0.1018 0.38 0.38
0.0303 0.4381 0.8854
0.1006 0.3228 0.6769
0.2238 0.4252 0.4252
0.0533 0.5972 0.6584
0.1822 0.3003 0.3003
1.6312 0.8166 1
0.6053 0.5425 0.5425

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_04875 (Loa Loa (eye worm)), alpha-L-fucosidase
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