Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0043 | 0.0174 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0256 | 0.2005 | 0.1863 |
Schistosoma mansoni | alpha-l-fucosidase | 0.1019 | 0.8568 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0447 | 0.3651 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1186 | 1 | 1 |
Brugia malayi | initiation factor 2-associated protein. | 0.0043 | 0.0174 | 0.0203 |
Trypanosoma brucei | Aph-1 protein, putative | 0.01 | 0.0664 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.01 | 0.0664 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0043 | 0.0174 | 0.5 |
Giardia lamblia | Methionine aminopeptidase | 0.0043 | 0.0174 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0447 | 0.3651 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1186 | 1 | 0.5 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0256 | 0.2005 | 0.234 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0043 | 0.0174 | 0.5 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0043 | 0.0174 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.1774 | 0.2071 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.1019 | 0.8568 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.01 | 0.0664 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.1774 | 0.2071 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0043 | 0.0174 | 0.5 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.1019 | 0.8568 | 1 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0043 | 0.0174 | 0.0203 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0256 | 0.2005 | 0.234 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0256 | 0.2005 | 0.2181 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0043 | 0.0174 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0256 | 0.2005 | 0.1863 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.