Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, AMPA 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | glutamate receptor, ionotropic, AMPA 2 | 883 aa | 810 aa | 34.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.4395 | 0.4625 |
Schistosoma mansoni | glutamate receptor kainate | 0.003 | 0.2516 | 0.5099 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.3274 | 0.3274 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0223 | 0.0223 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.3274 | 0.3274 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0062 | 0.6726 | 0.6726 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.003 | 0.2516 | 0.2542 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.4934 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.3274 | 0.3274 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0051 | 0.5248 | 0.5248 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.4008 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0081 | 0.9242 | 0.9242 |
Echinococcus granulosus | glutamate receptor 4 | 0.0051 | 0.5248 | 0.5248 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.3619 | 0.3765 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.3274 | 0.3274 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.5248 | 0.5572 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0223 | 0.0223 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.003 | 0.2516 | 0.2516 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0076 | 0.8522 | 0.8522 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0087 | 1 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0081 | 0.9242 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0081 | 0.9242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.5248 | 0.5572 |
Echinococcus granulosus | glutamate receptor 1 | 0.0051 | 0.5248 | 0.5248 |
Echinococcus granulosus | glutamate receptor 2 | 0.0076 | 0.8522 | 0.8522 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.5248 | 0.5572 |
Schistosoma mansoni | glutamate receptor kainate | 0.003 | 0.2516 | 0.5099 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0036 | 0.3274 | 0.3274 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0081 | 0.9242 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0223 | 0.0453 |
Schistosoma mansoni | glutamate receptor NMDA | 0.003 | 0.2516 | 0.5099 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0223 | 0.0223 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.4395 | 0.4395 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0062 | 0.6726 | 0.6726 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0223 | 0.0453 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.4934 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.003 | 0.2516 | 0.2516 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0036 | 0.3274 | 0.6635 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.003 | 0.2516 | 0.5099 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0087 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0087 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.003 | 0.2516 | 0.5099 |
Schistosoma mansoni | glutamate receptor AMPA | 0.003 | 0.2516 | 0.5099 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.4008 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.4395 | 0.4625 |
Schistosoma mansoni | glutamate receptor AMPA | 0.003 | 0.2516 | 0.5099 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.4395 | 0.4395 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0223 | 0.0223 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.3274 | 0.3274 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 48 % | Positive modulation of human GluA2 flip receptor by FLIPR assay relative to cyclothiazide | ChEMBL. | 20971003 |
EC50 (binding) | = 6.2 uM | Positive modulation of human GluA2 flip receptor by FLIPR assay | ChEMBL. | 20971003 |
IC50 (binding) | = 0.8 uM | Displacement of [3H]-dofetilide from human hERG | ChEMBL. | 20971003 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.