Detailed information for compound 1271985

Basic information

Technical information
  • TDR Targets ID: 1271985
  • Name: N-(2-adamantylideneamino)oxamide
  • MW: 235.282 | Formula: C12H17N3O2
  • H donors: 2 H acceptors: 2 LogP: 0.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)N)N/N=C/1\C2CC3CC1CC(C2)C3
  • InChi: 1S/C12H17N3O2/c13-11(16)12(17)15-14-10-8-2-6-1-7(4-8)5-9(10)3-6/h6-9H,1-5H2,(H2,13,16)(H,15,17)/b14-10-
  • InChiKey: XRVWDYPKWSXNBV-UVTDQMKNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-adamantylideneamino)ethanediamide
  • ZINC05163911
  • MLS001004517
  • SMR000348065
  • T0519-6330

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0101 0.0383 0.4162
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0101 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0051 0.0001 0.0001
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0101 0.0383 0.0382
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0101 0.0383 0.0382
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0101 0.0383 0.4162
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0066 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0116 0.3
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0101 0.0383 0.0383
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0066 0.0116 0.3
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0525 0.5709
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0101 0.0383 0.0382
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0066 0.0116 0.0115
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0101 0.0383 0.4162
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0101 0.0383 0.4162
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0116 0.3
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0919 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0525 0.5709
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.0116 0.0116
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0101 0.0383 0.0383
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0101 0.0383 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0383 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 0.5
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0101 0.0383 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0101 0.0383 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0066 0.0116 0.3
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0383 1
Giardia lamblia hypothetical protein 0.0101 0.0383 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Plasmodium vivax phosphodiesterase gamma, putative 0.0101 0.0383 0.5
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0101 0.0383 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0101 0.0383 0.0383
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0101 0.0383 0.0382
Schistosoma mansoni lipoxygenase 0.012 0.0537 0.0536
Echinococcus multilocularis protein dispatched 1 0.0058 0.0057 0.0606
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0383 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0101 0.0383 0.5
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0101 0.0383 0.5
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0066 0.0116 0.3
Trichomonas vaginalis guanylate cyclase, putative 0.0066 0.0116 0.3
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0525 0.0525
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0101 0.0383 0.0382
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0383 1
Loa Loa (eye worm) PDE1B protein 0.0101 0.0383 0.0383
Leishmania major hypothetical protein, conserved 0.0101 0.0383 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.0537 0.5834
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0066 0.0116 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0101 0.0383 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0383 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0525 0.0525
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0101 0.0383 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0101 0.0383 0.4162
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Brugia malayi PAS domain containing protein 0.0066 0.0116 0.0116
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0066 0.0116 0.1249
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0066 0.0116 0.3
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0101 0.0383 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0383 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0101 0.0383 0.4162
Loa Loa (eye worm) hypothetical protein 0.1346 1 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0101 0.0383 0.4162
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0116 0.3
Loa Loa (eye worm) hypothetical protein 0.0101 0.0383 0.0383
Onchocerca volvulus 0.0066 0.0116 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0101 0.0383 0.4162
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Brugia malayi CHE-14 protein 0.0051 0.0001 0.0001
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0101 0.0383 0.4162
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0101 0.0383 0.4162
Loa Loa (eye worm) hypothetical protein 0.1245 0.9224 0.9224
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0525 0.5
Trichomonas vaginalis adenylate cyclase, putative 0.0066 0.0116 0.3
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0539 0.0538
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0101 0.0383 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0101 0.0383 0.0382
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0101 0.0383 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0101 0.0383 0.5
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0066 0.0116 0.3
Loa Loa (eye worm) hypothetical protein 0.1245 0.9224 0.9224
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0101 0.0383 0.4162
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.1346 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0919 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.009 0.009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0101 0.0383 1
Schistosoma mansoni single-minded 0.0066 0.0116 0.0115
Trypanosoma brucei hypothetical protein, conserved 0.0101 0.0383 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0066 0.0116 0.1249
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0066 0.0116 0.1249
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus granulosus expressed conserved protein 0.0112 0.047 0.5102
Trichomonas vaginalis guanylate cyclase, putative 0.0066 0.0116 0.3
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.0537 0.5834
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0101 0.0383 0.0382
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Leishmania major hypothetical protein, conserved 0.0101 0.0383 1
Schistosoma mansoni lipoxygenase 0.0084 0.0257 0.0256
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0101 0.0383 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0383 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0101 0.0383 1
Giardia lamblia Hypothetical protein 0.0101 0.0383 0.5
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.1346 1 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0101 0.0383 0.5
Loa Loa (eye worm) hypothetical protein 0.0101 0.0383 0.0383
Echinococcus multilocularis expressed conserved protein 0.0112 0.047 0.5102
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Echinococcus granulosus aryl hydrocarbon receptor 0.0066 0.0116 0.1249
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0101 0.0383 0.4162
Loa Loa (eye worm) hypothetical protein 0.0101 0.0383 0.0383
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0101 0.0383 0.4162
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0101 0.0383 0.4162
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0101 0.0383 0.4162
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Brugia malayi hypothetical protein 0.0066 0.0116 0.0116
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0101 0.0383 0.4162
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 0.5
Loa Loa (eye worm) hypothetical protein 0.1245 0.9224 0.9224
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0101 0.0383 0.0382
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0383 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0101 0.0383 0.0382
Loa Loa (eye worm) hypothetical protein 0.0066 0.0116 0.0116
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0101 0.0383 0.0383
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0001 0.0001
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0101 0.0383 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0383 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0101 0.0383 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0101 0.0383 1
Mycobacterium leprae Possible regulatory protein 0.0066 0.0116 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0101 0.0383 1
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0383 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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