Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | wingless-type MMTV integration site family, member 3A | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Mus musculus | transient receptor potential cation channel, subfamily C, member 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Echinococcus multilocularis | short transient receptor potential channel 6 | transient receptor potential cation channel, subfamily C, member 4 | 890 aa | 799 aa | 31.2 % |
Brugia malayi | Wnt-2 protein precursor | wingless-type MMTV integration site family, member 3A | 352 aa | 355 aa | 39.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase II | 0.0427 | 0.3418 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0274 | 0.1938 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0231 | 0.1524 | 0.4398 |
Onchocerca volvulus | Putative sulfate transporter | 0.0202 | 0.124 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0117 | 0.0422 | 0.1136 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1267 | 0.3638 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0427 | 0.3418 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0117 | 0.0422 | 0.1136 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0231 | 0.1524 | 0.4398 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0427 | 0.3418 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0427 | 0.3418 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0231 | 0.1524 | 0.4398 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0231 | 0.1524 | 0.4398 |
Toxoplasma gondii | hypothetical protein | 0.0231 | 0.1524 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0231 | 0.1524 | 0.4398 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0117 | 0.0422 | 0.1136 |
Echinococcus granulosus | carbonic anhydrase II | 0.0427 | 0.3418 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0231 | 0.1524 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1267 | 0.3638 |
Echinococcus granulosus | carbonic anhydrase | 0.0231 | 0.1524 | 0.4398 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0427 | 0.3418 | 1 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0117 | 0.0422 | 0.1136 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0231 | 0.1524 | 0.432 |
Echinococcus granulosus | carbonic anhydrase | 0.0231 | 0.1524 | 0.4398 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0231 | 0.1524 | 0.432 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.0453 | 0.1324 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0233 | 0.1543 | 0.1263 |
Schistosoma mansoni | carbonic anhydrase | 0.0231 | 0.1524 | 0.4398 |
Onchocerca volvulus | 0.0202 | 0.124 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1267 | 0.3638 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0113 | 0.0384 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1524 | 0.446 |
Leishmania major | carbonic anhydrase-like protein | 0.0427 | 0.3418 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0231 | 0.1524 | 0.4398 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0379 | 0.2956 | 0.3016 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0961 | 0.8587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1524 | 0.446 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0427 | 0.3418 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0427 | 0.3418 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0427 | 0.3418 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0231 | 0.1524 | 0.4398 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0231 | 0.1524 | 0.432 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1524 | 0.446 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0274 | 0.1938 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.1267 | 0.3638 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0084 | 0.0246 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0231 | 0.1524 | 0.432 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0231 | 0.1524 | 0.446 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.0453 | 0.1105 |
Schistosoma mansoni | carbonic anhydrase | 0.0274 | 0.1938 | 0.5621 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1107 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0084 | 0.0137 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1107 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0427 | 0.3418 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0113 | 0.0384 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0422 | 0.1234 |
Echinococcus granulosus | carbonic anhydrase | 0.0231 | 0.1524 | 0.4398 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0427 | 0.3418 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0453 | 0.1324 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.0453 | 0.1105 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0231 | 0.1524 | 0.432 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0.376 uM | PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256] | ChEMBL. | No reference |
EC50 (functional) | 0.944 uM | PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2237, AID2259] | ChEMBL. | No reference |
IC50 (functional) | 4.3 uM | PubChem BioAssay. Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 20 uM | PubChem BioAssay. Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.0058 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3109 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.