Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | STE family protein kinase | 0.0206 | 0.1348 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0206 | 0.1348 | 0.1725 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.1305 | 0.1305 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0206 | 0.1348 | 0.1725 |
Entamoeba histolytica | protein kinase, putative | 0.013 | 0.0043 | 0.032 |
Trichomonas vaginalis | STE family protein kinase | 0.0206 | 0.1348 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0206 | 0.1348 | 0.1725 |
Schistosoma mansoni | protein kinase | 0.0206 | 0.1348 | 1 |
Brugia malayi | Protein kinase domain | 0.0206 | 0.1348 | 0.1348 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0582 | 0.7811 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0206 | 0.1348 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0582 | 0.7811 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0203 | 0.1305 | 0.9669 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0206 | 0.1348 | 0.1725 |
Trichomonas vaginalis | STE family protein kinase | 0.0206 | 0.1348 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.013 | 0.0043 | 0.0055 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0709 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0206 | 0.1348 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0206 | 0.1348 | 1 |
Schistosoma mansoni | protein kinase | 0.013 | 0.0043 | 0.032 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0206 | 0.1348 | 0.1725 |
Entamoeba histolytica | protein kinase, putative | 0.013 | 0.0043 | 0.032 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0206 | 0.1348 | 0.1725 |
Schistosoma mansoni | protein kinase | 0.0206 | 0.1348 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.013 | 0.0043 | 0.032 |
Giardia lamblia | Kinase, STE STE20 | 0.0206 | 0.1348 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.