TDR Targets

Basic information

Technical information

TDR Targets ID: 1277989
Name: 4-chloro-3-methyl-N-pyridin-3-yl-1,2-oxazole- 5-carboxamide
MW: 237.642 | Formula: C10H8ClN3O2
H donors: 1 H acceptors: 3 LogP: 1.5 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1onc(c1Cl)C)Nc1cccnc1
InChi: 1S/C10H8ClN3O2/c1-6-8(11)9(16-14-6)10(15)13-7-3-2-4-12-5-7/h2-5H,1H3,(H,13,15)
InChiKey: PCBOWUMFODXMSI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-chloro-3-methyl-N-(3-pyridyl)isoxazole-5-carboxamide
4-chloro-3-methyl-N-(3-pyridyl)-5-isoxazolecarboxamide
MLS000522581
SMR000127848

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Uncharacterized LmbE-like protein, COG2120 containing protein	0.004	0.0047	0.012
Mycobacterium tuberculosis	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)	0.004	0.0047	0.0047
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0192	0.0481	0.1085
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0192	0.0481	0.1238
Loa Loa (eye worm)	UDP galactose 4'-epimerase	0.0045	0.0061	0.0137
Echinococcus granulosus	histone deacetylase 1	0.0383	0.1027	0.2316
Trypanosoma brucei	histone deacetylase 2	0.0153	0.0372	0.3619
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0016	0.0041
Plasmodium vivax	histone deacetylase, putative	0.0153	0.0372	0.3316
Schistosoma mansoni	cpg binding protein	0.0029	0.0016	0.0036
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Giardia lamblia	UDP-glucose 4-epimerase	0.0043	0.0056	0.0127
Toxoplasma gondii	histone deacetylase HDAC3	0.0383	0.1027	0.2235
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0481	0.4685
Trypanosoma cruzi	histone deacetylase, putative	0.0153	0.0372	0.3619
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Trichomonas vaginalis	UDP-glucose 4-epimerase, putative	0.0045	0.0061	0.0592
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0192	0.0481	0.1085
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.1383	0.3887	0.8765
Plasmodium falciparum	histone deacetylase 2	0.0297	0.0783	0.7509
Toxoplasma gondii	histone deacetylase HDAC5	0.0153	0.0372	0.0741
Trypanosoma cruzi	hypothetical protein, conserved	0.0192	0.0481	0.4685
Onchocerca volvulus		0.0033	0.0028	0.0348
Echinococcus multilocularis	cpg binding protein	0.0029	0.0016	0.0036
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0192	0.0481	0.4432
Loa Loa (eye worm)	histone deacetylase 3	0.0383	0.1027	0.2316
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Trichomonas vaginalis	histone deacetylase, putative	0.0383	0.1027	1
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Trypanosoma cruzi	hypothetical protein, conserved	0.0192	0.0481	0.4685
Plasmodium falciparum	histone deacetylase, putative	0.0297	0.0783	0.7509
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0091	0.0206
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0481	0.1085
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0192	0.0481	0.1085
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus multilocularis	histone deacetylase 6	0.0297	0.0783	0.1766
Giardia lamblia	Hypothetical protein	0.0192	0.0481	0.1085
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0016	0.0036
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0192	0.0481	0.1085
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0192	0.0481	0.4685
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0192	0.0481	0.1085
Trypanosoma brucei	UDP-galactose 4-epimerase	0.0043	0.0056	0.0549
Leishmania major	udp-glc 4-epimerase, putative	0.0043	0.0056	0.0549
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0192	0.0481	0.1085
Trypanosoma cruzi	histone deacetylase, putative	0.0297	0.0783	0.7622
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0383	0.1027	1
Brugia malayi	Histone deacetylase 1	0.0383	0.1027	0.2643
Entamoeba histolytica	UDP-glucose 4-epimerase, putative	0.0045	0.0061	0.0592
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0192	0.0481	0.1085
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0192	0.0481	0.1085
Echinococcus multilocularis	histone deacetylase 6	0.0313	0.0827	0.1866
Trichomonas vaginalis	histone deacetylase, putative	0.0383	0.1027	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0383	0.1027	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.1574	0.4435	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0372	0.0838
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0192	0.0481	0.1085
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Giardia lamblia	Histone deacetylase	0.0383	0.1027	0.2316
Echinococcus multilocularis	histone deacetylase	0.0297	0.0783	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0389	0.0877
Echinococcus granulosus	histone deacetylase	0.0297	0.0783	0.1766
Leishmania major	histone deacetylase, putative	0.0383	0.1027	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Leishmania major	hypothetical protein, conserved	0.0192	0.0481	0.4685
Plasmodium vivax	phosphodiesterase gamma, putative	0.0192	0.0481	0.4432
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Echinococcus multilocularis	N acetylglucosaminyl phosphatidylinositol	0.004	0.0047	0.0105
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0192	0.0481	0.4685
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0192	0.0481	0.1085
Schistosoma mansoni	histone deacetylase 4 5	0.0297	0.0783	0.1766
Echinococcus granulosus	histone deacetylase 7	0.0297	0.0783	0.1766
Loa Loa (eye worm)	phosphatidylinositol glycan anchor biosynthesis protein	0.004	0.0047	0.0105
Brugia malayi	histone deacetylase 11	0.0153	0.0372	0.0956
Loa Loa (eye worm)	histone deacetylase 7A	0.0297	0.0783	0.1766
Trypanosoma cruzi	histone deacetylase 1, putative	0.0383	0.1027	1
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0481	0.4685
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0192	0.0481	0.4432
Trichomonas vaginalis	histone deacetylase, putative	0.0383	0.1027	1
Leishmania major	hypothetical protein, conserved	0.0192	0.0481	0.4685
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0153	0.0372	1
Schistosoma mansoni	UDP-glucose 4-epimerase	0.0045	0.0061	0.0137
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.1574	0.4435	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0091	0.0206
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.1574	0.4435	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0383	0.1027	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0091	0.0206
Trypanosoma cruzi	histone deacetylase, putative	0.0297	0.0783	0.7622
Brugia malayi	Histone deacetylase family protein	0.0297	0.0783	0.2014
Plasmodium vivax	histone deacetylase, putative	0.0297	0.0783	0.7509
Echinococcus granulosus	histone deacetylase 3	0.0383	0.1027	0.2316
Echinococcus granulosus	UDP glucose 4 epimerase	0.0045	0.0061	0.0137
Schistosoma mansoni	histone deacetylase hda2	0.0313	0.0827	0.1866
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0192	0.0481	0.1085
Loa Loa (eye worm)	histone deacetylase 11	0.0153	0.0372	0.0838
Brugia malayi	histone deacetylase 1 (HD1)	0.0383	0.1027	0.2643
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus granulosus	cpg binding protein	0.0029	0.0016	0.0036
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0091	0.0206
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Loa Loa (eye worm)	histone deacetylase	0.0297	0.0783	0.1766
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trypanosoma cruzi	histone deacetylase, putative	0.0297	0.0783	0.7622
Schistosoma mansoni	histone deacetylase hda2	0.0153	0.0372	0.0838
Schistosoma mansoni	cpg binding protein	0.0029	0.0016	0.0036
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0045	0.0061	0.0592
Leishmania major	N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase	0.004	0.0047	0.0453
Schistosoma mansoni	cpg binding protein	0.0029	0.0016	0.0036
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0192	0.0481	0.1085
Echinococcus granulosus	histone deacetylase 8	0.0153	0.0372	0.0838
Trichomonas vaginalis	conserved hypothetical protein	0.0192	0.0481	0.4685
Trypanosoma cruzi	histone deacetylase, putative	0.0153	0.0372	0.3619
Trichomonas vaginalis	histone deacetylase, putative	0.0383	0.1027	1
Schistosoma mansoni	histone deacetylase	0.0383	0.1027	0.2316
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0481	0.1085
Brugia malayi	Disco-interacting protein 2 homolog	0.0033	0.0028	0.0073
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4432
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Giardia lamblia	hypothetical protein	0.0192	0.0481	0.1085
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0192	0.0481	0.1238
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0192	0.0481	0.4432
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.004	0.0047	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0481	0.1085
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Trypanosoma cruzi	UDP-galactose 4-epimerase, putative	0.0045	0.0061	0.0592
Loa Loa (eye worm)	hypothetical protein	0.1574	0.4435	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0028	0.0064
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.1383	0.3887	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.1574	0.4435	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Mycobacterium tuberculosis	Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase)	0.3481	0.9887	1
Trypanosoma brucei	hypothetical protein, conserved	0.0192	0.0481	0.4685
Plasmodium falciparum	phosphodiesterase delta, putative	0.0192	0.0481	0.4432
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0192	0.0481	0.1085
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0192	0.0481	0.1238
Trichomonas vaginalis	histone deacetylase, putative	0.0383	0.1027	1
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0192	0.0481	0.1085
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0192	0.0481	0.4685
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0091	0.0235
Toxoplasma gondii	UDP-glucose 4-epimerase	0.0045	0.0061	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0383	0.1027	0.2316
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Toxoplasma gondii	histone deacetylase HDAC1	0.0297	0.0783	0.1678
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0192	0.0481	0.1085
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0073	0.0142	0.0974
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0192	0.0481	0.4685
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0192	0.0481	0.1085
Echinococcus multilocularis	disco interacting protein 2	0.0033	0.0028	0.0064
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4432
Brugia malayi	UDP galactose 4'-epimerase	0.0045	0.0061	0.0157
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0192	0.0481	0.1085
Leishmania major	histone deacetylase, putative	0.0297	0.0783	0.7622
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0192	0.0481	0.1085
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.1574	0.4435	1
Leishmania major	histone deacetylase, putative	0.0297	0.0783	0.7622
Toxoplasma gondii	histone deacetylase HDAC4	0.0153	0.0372	0.0741
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus multilocularis	histone deacetylase 6	0.0297	0.0783	0.1766
Trypanosoma brucei	histone deacetylase, putative	0.0297	0.0783	0.7622
Loa Loa (eye worm)	PDE1B protein	0.0192	0.0481	0.1085
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus granulosus	N acetylglucosaminyl phosphatidylinositol	0.004	0.0047	0.0105
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0192	0.0481	0.1085
Echinococcus multilocularis	histone deacetylase 1	0.0383	0.1027	0.2316
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.1383	0.3887	0.8765
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.1574	0.4435	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0192	0.0481	0.1085
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0091	0.0206
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Echinococcus multilocularis	histone deacetylase 3	0.0383	0.1027	0.2316
Trypanosoma cruzi	hypothetical protein, conserved	0.0192	0.0481	0.4685
Trypanosoma brucei	histone deacetylase 3	0.0297	0.0783	0.7622
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0383	0.1027	1
Entamoeba histolytica	histone deacetylase, putative	0.0383	0.1027	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0192	0.0481	0.4685
Trichomonas vaginalis	histone deacetylase, putative	0.0383	0.1027	1
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4432
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Loa Loa (eye worm)	histone deacetylase 1	0.0383	0.1027	0.2316
Toxoplasma gondii	histone deacetylase HDAC2	0.0383	0.1027	0.2235
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4432
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.1383	0.3887	0.8765
Plasmodium falciparum	histone deacetylase 1	0.0383	0.1027	1
Trypanosoma brucei	N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase	0.004	0.0047	0.0453
Trypanosoma cruzi	hypothetical protein, conserved	0.0192	0.0481	0.4685
Toxoplasma gondii	hypothetical protein	0.0073	0.0142	0.0218
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.004	0.0047	0.0453
Echinococcus granulosus	histone deacetylase 6	0.0297	0.0783	0.1766
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Mycobacterium ulcerans	mycothiol conjugate amidase Mca	0.352	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.1574	0.4435	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0192	0.0481	0.1085
Brugia malayi	histone deacetylase 3 (HD3)	0.0383	0.1027	0.2643
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0091	0.0206
Schistosoma mansoni	histone deacetylase 4 5	0.0297	0.0783	0.1766
Trypanosoma brucei	histone deacetylase 1	0.0383	0.1027	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0192	0.0481	0.1085
Leishmania major	histone deacetylase, putative	0.0383	0.1027	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0192	0.0481	0.1238
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0045	0.0061	0.0592
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0091	0.0206
Entamoeba histolytica	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative	0.004	0.0047	0.0453
Echinococcus granulosus	histone deacetylase 6	0.0297	0.0783	0.1766
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0192	0.0481	0.1085
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4432
Brugia malayi	Histone deacetylase family protein	0.0297	0.0783	0.2014
Echinococcus granulosus	disco interacting protein 2	0.0033	0.0028	0.0064
Schistosoma mansoni	disco-interacting protein 2 (dip2)	0.0033	0.0028	0.0064
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0192	0.0481	0.4685
Trypanosoma cruzi	hypothetical protein, conserved	0.0192	0.0481	0.4685
Plasmodium vivax	histone deacetylase 1, putative	0.0383	0.1027	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Entamoeba histolytica	glucosamine-6-phosphate isomerase, putative	0.004	0.0047	0.0453
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0091	0.0206
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0192	0.0481	0.4685
Echinococcus multilocularis	histone deacetylase 7	0.0297	0.0783	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0345	0.0777
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0192	0.0481	0.4685
Echinococcus multilocularis	histone deacetylase 8	0.0153	0.0372	0.0838
Trypanosoma brucei	histone deacetylase 4	0.0297	0.0783	0.7622
Trypanosoma cruzi	UDP-galactose 4-epimerase	0.0045	0.0061	0.0592
Schistosoma mansoni	histone deacetylase	0.0383	0.1027	0.2316
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0192	0.0481	0.4685
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0192	0.0481	0.1238
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Schistosoma mansoni	histone deacetylase 1 2 3	0.0153	0.0372	0.0838
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.004	0.0047	0.0453
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0192	0.0481	0.1238
Plasmodium vivax	histone deacetylase 2, putative	0.0297	0.0783	0.7509
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.0047	0.0047
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0192	0.0481	0.0991
Mycobacterium ulcerans	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB	0.004	0.0047	0.0047
Schistosoma mansoni	N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase	0.004	0.0047	0.0105
Echinococcus multilocularis	UDP glucose 4 epimerase	0.0045	0.0061	0.0137
Echinococcus granulosus	histone deacetylase 6	0.0313	0.0827	0.1866
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0192	0.0481	0.4685
Giardia lamblia	Glucosamine-6-phosphate isomerase, putative	0.004	0.0047	0.0105

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.1 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1386602

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1277989