Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.5408 | 0.4775 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2991 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.2991 | 0.2025 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.5408 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2991 | 0.2025 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1211 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.2991 | 0.2025 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2991 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2991 | 0.2025 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1211 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1211 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1211 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.2991 | 0.2991 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.5408 | 0.4775 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1211 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1211 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1211 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1211 | 0.1211 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1211 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2991 | 0.2025 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.2991 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 68.253 uM | PUBCHEM_BIOASSAY: High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1007, AID1008, AID1009, AID1240, AID1243, AID1244, AID1245, AID1320, AID1322, AID1327, AID1328, AID1329, AID1330, AID1693, AID2075, AID2077, AID2080, AID2081, AID2084, AID2086, AID432, AID504598, AID950, AID951, AID952] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.