Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0476 | 0.2748 | 0.6834 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.358 | 0.3368 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0476 | 0.2748 | 0.2941 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0562 | 0.358 | 0.933 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0367 | 0.1708 | 0.1599 |
Loa Loa (eye worm) | matrixin family protein | 0.0406 | 0.2079 | 0.1817 |
Brugia malayi | Matrixin family protein | 0.0822 | 0.6075 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0644 | 0.4365 | 0.5028 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0586 | 0.3804 | 1 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0277 | 0.0834 | 0.1373 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.1045 | 0.8217 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1045 | 0.8217 | 1 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.052 | 0.3176 | 0.5229 |
Brugia malayi | Hemopexin family protein | 0.026 | 0.0672 | 0.1106 |
Schistosoma mansoni | hypothetical protein | 0.026 | 0.0672 | 0.0608 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0223 | 0.032 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0822 | 0.6075 | 0.5945 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0223 | 0.032 | 0.0527 |
Mycobacterium ulcerans | hydrolase | 0.0223 | 0.032 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0586 | 0.3804 | 0.4304 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0406 | 0.2079 | 0.2786 |
Onchocerca volvulus | Matrilysin homolog | 0.0785 | 0.5723 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0367 | 0.1708 | 0.1599 |
Brugia malayi | hypothetical protein | 0.0239 | 0.0469 | 0.0772 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 0.3176 | 0.2951 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0476 | 0.2748 | 0.2941 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0223 | 0.032 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.