Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0486 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0486 | 1 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0124 | 0.2186 | 0.2186 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0124 | 0.2186 | 0.2186 |
Brugia malayi | Sodium:solute symporter family protein | 0.0124 | 0.2186 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0486 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0124 | 0.2186 | 0.2186 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0486 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2186 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0124 | 0.2186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2186 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0486 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0486 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0124 | 0.2186 | 0.2186 |
Schistosoma mansoni | sodium/solute symporter | 0.0124 | 0.2186 | 0.2186 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | high-affinity choline transporter | 0.0124 | 0.2186 | 0.2186 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Brugia malayi | GH02984p | 0.0124 | 0.2186 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0486 | 1 | 1 |
Onchocerca volvulus | 0.0124 | 0.2186 | 0.5 | |
Echinococcus granulosus | solute carrier family 5 | 0.0486 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0042 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.6573 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.