Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.2529 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.2529 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.2574 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0043 | 0.0169 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0043 | 0.0169 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0312 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.0043 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0043 | 0.0169 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.2529 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0043 | 0.0169 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0016 | 0.0312 | 0.1063 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.7738 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.2574 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0043 | 0.0169 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0.0312 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.2529 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.2529 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.7738 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.2529 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.7738 | 1 |
Leishmania major | trypanothione reductase | 0.0046 | 0.2529 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0016 | 0.0312 | 0.1063 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.2529 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.6874 | 0.8837 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.0043 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.0043 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0016 | 0.0312 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0043 | 0.0169 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0043 | 0.0169 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0043 | 0.0169 |
Onchocerca volvulus | 0.0012 | 0.0043 | 0.5 | |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.2529 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0043 | 0.0169 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0016 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0043 | 0.0169 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0043 | 0.0169 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0043 | 0.0169 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0312 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0043 | 0.0169 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0043 | 0.0169 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0016 | 0.0312 | 0.027 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0016 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0043 | 0.0169 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.6874 | 0.8837 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0043 | 0.0169 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.7738 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.2529 | 0.2985 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0043 | 0.0169 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0312 | 0.1234 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.2529 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.2529 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0043 | 0.0169 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.6874 | 0.8837 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0043 | 0.0169 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0.0312 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0043 | 0.0169 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3548 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.