Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | amidase | 0.0116 | 0.188 | 0.1678 |
Schistosoma mansoni | tyrosinase precursor | 0.0091 | 0.1343 | 0.1572 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0499 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0091 | 0.1343 | 0.1572 |
Brugia malayi | ShTK domain containing protein | 0.0091 | 0.1343 | 0.1128 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0116 | 0.188 | 0.1083 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.0894 | 0.0667 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0091 | 0.1343 | 0.1288 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0499 | 1 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0091 | 0.1343 | 0.1288 |
Leishmania major | hypothetical protein, conserved | 0.0499 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0306 | 0.0306 |
Trypanosoma brucei | lipase domain protein, putative | 0.0499 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.188 | 0.1829 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0243 | 0.0181 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0116 | 0.188 | 0.1083 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.0894 | 0.0894 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0091 | 0.1343 | 0.1288 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.0894 | 0.0894 |
Onchocerca volvulus | 0.0091 | 0.1343 | 0.1288 | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0116 | 0.188 | 0.1083 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1343 | 0.1288 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0091 | 0.1343 | 0.1128 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0091 | 0.1343 | 0.1128 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1343 | 0.1288 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0499 | 1 | 1 |
Loa Loa (eye worm) | lipase | 0.0499 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.3754 | 0.3141 |
Onchocerca volvulus | 0.0499 | 1 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0091 | 0.1343 | 0.1128 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0499 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0306 | 0.0306 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0091 | 0.1343 | 0.1128 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0116 | 0.188 | 0.1083 |
Trypanosoma brucei | lipase domain protein, putative | 0.0499 | 1 | 0.5 |
Onchocerca volvulus | 0.0091 | 0.1343 | 0.1288 | |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0116 | 0.188 | 0.3449 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3754 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0306 | 0.0244 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.0894 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0243 | 0.0181 |
Echinococcus granulosus | geminin | 0.0205 | 0.3754 | 0.3141 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0091 | 0.1343 | 0.1128 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0499 | 1 | 1 |
Schistosoma mansoni | amidase | 0.0116 | 0.188 | 0.3449 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0499 | 1 | 0.5 |
Onchocerca volvulus | 0.0091 | 0.1343 | 0.1288 | |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3754 | 1 |
Onchocerca volvulus | 0.0091 | 0.1343 | 0.1288 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0243 | 0.0243 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.