Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.6906 | 0.8837 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0313 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0313 | 0.0405 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.254 | 1 |
Leishmania major | trypanothione reductase | 0.0048 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.6906 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.7773 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.254 | 0.3284 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.6906 | 0.8837 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.7736 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0017 | 0.0313 | 0.5 |
Brugia malayi | glutathione reductase | 0.0048 | 0.254 | 0.3284 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.7773 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.254 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0313 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.254 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.254 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.254 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.254 | 0.2985 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0017 | 0.0313 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.254 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.254 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0017 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.7773 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.7736 | 1 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0313 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.254 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0313 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.6906 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0313 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0313 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.7736 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.