Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0012 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0012 | 0.0012 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0071 | 0.1156 | 0.1156 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0136 | 0.3284 | 0.3284 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.2546 | 0.9188 |
Onchocerca volvulus | 0.005 | 0.0458 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0012 | 0.0032 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.2771 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0113 | 0.2546 | 0.9188 |
Schistosoma mansoni | jumonji domain containing protein | 0.0071 | 0.1156 | 0.3175 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0458 | 0.1652 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0071 | 0.1156 | 0.1156 |
Echinococcus multilocularis | tumor protein p63 | 0.034 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.3284 | 0.9016 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 0.3642 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0012 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1368 | 0.4935 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.1156 | 0.1156 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.2771 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.1156 | 0.4173 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0012 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.1368 | 0.3755 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.1156 | 0.3175 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0071 | 0.1156 | 0.1156 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0012 | 0.0032 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.1368 | 0.4935 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.2771 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0012 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0136 | 0.3284 | 0.3284 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0012 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.1156 | 0.4173 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0458 | 0.1257 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0147 | 0.3642 | 0.3642 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.1156 | 0.3175 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 0.3642 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0113 | 0.2546 | 0.9188 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0113 | 0.2546 | 0.9188 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.1156 | 0.4173 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.