Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0248 | 0.827 | 0.827 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.005 | 0.1199 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.1134 | 0.1134 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.005 | 0.1199 | 0.1199 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1134 | 0.1134 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0154 | 0.4891 | 0.4891 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.4163 | 0.4163 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.005 | 0.1199 | 0.2881 |
Brugia malayi | isocitrate dehydrogenase | 0.005 | 0.1199 | 0.1199 |
Mycobacterium ulcerans | glutaminase | 0.0296 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.3152 | 0.3152 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.005 | 0.1199 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.1134 | 0.2724 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.4163 | 0.4163 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.005 | 0.1199 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.1199 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.005 | 0.1199 | 0.2881 |
Schistosoma mansoni | glutaminase | 0.0296 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1134 | 0.1134 |
Brugia malayi | Isocitrate dehydrogenase | 0.005 | 0.1199 | 0.1199 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.005 | 0.1199 | 0.1199 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.3152 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.4891 | 0.4891 |
Loa Loa (eye worm) | glutaminase 2 | 0.0296 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.005 | 0.1199 | 0.2881 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.1199 | 0.2881 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0315 | 0.0315 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.1134 | 0.2724 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.005 | 0.1199 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.1199 | 0.2881 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.4163 | 0.4163 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.1134 | 0.2724 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.1134 | 0.2724 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.4163 | 0.4163 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.1134 | 0.2724 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.1199 | 1 |
Brugia malayi | TAR-binding protein | 0.0133 | 0.4163 | 0.4163 |
Trichomonas vaginalis | glutaminase, putative | 0.0296 | 1 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.1134 | 0.2724 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0248 | 0.827 | 0.827 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1134 | 0.1134 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.4163 | 0.4163 |
Brugia malayi | MH2 domain containing protein | 0.0248 | 0.827 | 0.827 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.005 | 0.1199 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.4163 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.1199 | 0.2881 |
Brugia malayi | RNA binding protein | 0.0133 | 0.4163 | 0.4163 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1134 | 0.1134 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.4163 | 0.4163 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.1199 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.005 | 0.1199 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.4163 | 0.4163 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.1134 | 0.1134 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.005 | 0.1199 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0154 | 0.4891 | 0.4891 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1134 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | glutaminase | 0.0296 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.4163 | 0.4163 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.4163 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0154 | 0.4891 | 0.4891 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.4163 | 0.4163 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.