Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Echinococcus granulosus | lysosome membrane protein 2 | 0.0544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0544 | 1 | 1 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.0544 | 1 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0186 | 0.0186 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.0544 | 1 | 1 |
Echinococcus multilocularis | lysosome membrane protein 2 | 0.0544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.3351 | 0.3225 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | Lysosome membrane protein 2 homolog | 0.0544 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0186 | 0.0186 |
Brugia malayi | hypothetical protein | 0.0205 | 0.3351 | 0.3351 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.3351 | 0.3225 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0224 | 0.372 | 0.3601 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.3351 | 0.3225 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0224 | 0.372 | 0.372 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0186 | 0.0186 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0186 | 0.0186 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Schistosoma mansoni | cd36 antigen | 0.0205 | 0.3351 | 0.3351 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0186 | 0.0186 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0205 | 0.3351 | 0.3351 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0544 | 1 | 1 |
Schistosoma mansoni | scavenger receptor class B type-2 (sr-B2) | 0.0544 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0186 | 0.0186 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0186 | 0.0186 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.