Detailed information for compound 1302928

Basic information

Technical information
  • TDR Targets ID: 1302928
  • Name: 5-amino-1-naphthalen-1-yl-4-phenyl-2H-pyrrol- 3-one
  • MW: 300.354 | Formula: C20H16N2O
  • H donors: 1 H acceptors: 1 LogP: 4.18 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CN(C(=C1c1ccccc1)N)c1cccc2c1cccc2
  • InChi: 1S/C20H16N2O/c21-20-19(15-8-2-1-3-9-15)18(23)13-22(20)17-12-6-10-14-7-4-5-11-16(14)17/h1-12H,13,21H2
  • InChiKey: UATKMEITNRWALT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-amino-1-(1-naphthyl)-4-phenyl-2H-pyrrol-3-one
  • 5-amino-1-(1-naphthyl)-4-phenyl-2-pyrrolin-3-one
  • T5662456
  • ZINC03216952
  • MLS001005188
  • SMR000378064

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0216 0.0546
Schistosoma mansoni hypothetical protein 0.0117 0.1381 0.3029
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0237 0.3957 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0368 0.675 0.6678
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0114 0.1328 0.3357
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0068 0.0336 0.085
Schistosoma mansoni hypothetical protein 0.0117 0.1381 0.3029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1328 0.3357
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.2851 0.2741
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.2851 1
Giardia lamblia DNA repair protein RAD52 0.0386 0.7124 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0237 0.3957 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0129 0.1642 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0114 0.1328 0.2901
Brugia malayi Probable ClpP-like protease 0.0237 0.3957 0.3824
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0156 0.2214 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1642 0.1458
Brugia malayi Pip kinase protein 2 0.0171 0.2548 0.2383
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.2851 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0117 0.1381 0.349
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0237 0.3957 0.5
Leishmania major hypothetical protein, conserved 0.0129 0.1642 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.3957 0.3824
Echinococcus granulosus muscleblind protein 0.018 0.2741 0.6927
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0128 0.1632 0.3429
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1328 0.7943
Brugia malayi hypothetical protein 0.0129 0.1642 0.1458
Plasmodium falciparum ataxin-2 like protein, putative 0.0129 0.1642 0.3022
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0156 0.2214 1
Echinococcus multilocularis muscleblind protein 0.018 0.2741 0.6927
Onchocerca volvulus 0.0186 0.2851 1
Brugia malayi Latrophilin receptor protein 2 0.0117 0.1381 0.1191
Schistosoma mansoni hypothetical protein 0.0252 0.4265 1
Brugia malayi latrophilin 2 splice variant baaae 0.0252 0.4265 0.4138
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0336 0.085
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0114 0.1328 0.3357
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0237 0.3957 1
Onchocerca volvulus 0.0171 0.2548 0.1583
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1328 0.3357
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1328 0.3357
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0114 0.1328 0.7943
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0171 0.2548 0.5849
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0186 0.2851 0.2693
Loa Loa (eye worm) hypothetical protein 0.018 0.2741 0.2581
Brugia malayi Isocitrate dehydrogenase 0.0114 0.1328 0.1137
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.2851 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1328 0.7943
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.007 0.0384 0.0171
Schistosoma mansoni peptidase Clp (S14 family) 0.0237 0.3957 0.9256
Trypanosoma cruzi PAB1-binding protein , putative 0.0129 0.1642 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.2851 0.2741
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.2812 0.2653
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0128 0.0323
Toxoplasma gondii isocitrate dehydrogenase 0.0114 0.1328 0.2075
Plasmodium falciparum ataxin-2 like protein, putative 0.0129 0.1642 0.3022
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0114 0.1328 0.2075
Echinococcus granulosus tar DNA binding protein 0.0062 0.0216 0.0546
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0386 0.7124 1
Echinococcus multilocularis GPCR, family 2 0.0117 0.1381 0.349
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0186 0.2851 0.2693
Loa Loa (eye worm) isocitrate dehydrogenase 0.0114 0.1328 0.1137
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0117 0.1381 0.349
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0117 0.1381 0.1191
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0368 0.675 0.6678
Loa Loa (eye worm) transcription factor SMAD2 0.0521 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0237 0.3957 1
Onchocerca volvulus Tyrosine kinase homolog 0.0172 0.2553 0.1719
Loa Loa (eye worm) pip kinase 2 0.0171 0.2548 0.2383
Loa Loa (eye worm) hypothetical protein 0.0252 0.4265 0.4138
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0171 0.2548 0.6438
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.2851 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0237 0.3957 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0128 0.0323
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0117 0.1381 0.349
Loa Loa (eye worm) latrophilin receptor protein 2 0.0117 0.1381 0.1191
Loa Loa (eye worm) MH2 domain-containing protein 0.0521 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0129 0.1642 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0171 0.2548 0.5849
Loa Loa (eye worm) hypothetical protein 0.0117 0.1381 0.1191
Loa Loa (eye worm) hypothetical protein 0.0171 0.2548 0.2383
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0216 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0216 0.0213
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0237 0.3957 1
Echinococcus granulosus GPCR family 2 0.0117 0.1381 0.349
Echinococcus granulosus peptidase Clp S14 family 0.0156 0.2214 0.5594
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0237 0.3957 1
Loa Loa (eye worm) hypothetical protein 0.0368 0.675 0.6678
Schistosoma mansoni hypothetical protein 0.0117 0.1381 0.3029
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0114 0.1328 0.2075
Brugia malayi Muscleblind-like protein 0.018 0.2741 0.2581
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0117 0.1381 0.349
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0336 0.085
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0216 0.0213
Echinococcus multilocularis isocitrate dehydrogenase 0.0114 0.1328 0.3357
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.2851 1
Echinococcus granulosus Glycosyl transferase family 8 0.007 0.0384 0.097
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0237 0.3957 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0237 0.3957 1
Schistosoma mansoni glycosyltransferase-related 0.007 0.0384 0.0618
Echinococcus multilocularis Glycosyl transferase, family 8 0.007 0.0384 0.097
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0237 0.3957 1
Brugia malayi isocitrate dehydrogenase 0.0114 0.1328 0.1137
Loa Loa (eye worm) hypothetical protein 0.018 0.2741 0.2581
Plasmodium vivax ataxin-2 like protein, putative 0.0129 0.1642 0.3022
Brugia malayi Glycosyl transferase family 8 protein 0.007 0.0384 0.0171
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0237 0.3957 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0216 0.0213
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0237 0.3957 1
Toxoplasma gondii isocitrate dehydrogenase 0.0114 0.1328 0.2075
Echinococcus multilocularis peptidase Clp (S14 family) 0.0156 0.2214 0.5594
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0171 0.2548 0.6438
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0156 0.2214 0.4744
Toxoplasma gondii LsmAD domain-containing protein 0.0129 0.1642 0.3022
Schistosoma mansoni hypothetical protein 0.0117 0.1381 0.3029
Brugia malayi hypothetical protein 0.0083 0.0669 0.0463
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.2812 0.2653
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.2851 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0216 0.0213
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0114 0.1328 0.7943
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1328 0.7943
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0336 0.085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0368 0.675 0.6678
Echinococcus multilocularis muscleblind protein 1 0.018 0.2741 0.6927

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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