TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.895 | Formula: C23H23ClN2O
H donors: 1 H acceptors: 2 LogP: 5.53 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(c1ccc(cc1)C)Nc1ccc(cc1Cl)C)CCc1ccncc1
InChi: 1S/C23H23ClN2O/c1-16-3-7-19(8-4-16)23(26-21-9-5-17(2)15-20(21)24)22(27)10-6-18-11-13-25-14-12-18/h3-5,7-9,11-15,23,26H,6,10H2,1-2H3
InChiKey: XJCCBILBHUUZJE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	corticotropin releasing hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR001879,Hormone receptor, extracellular,domain-containing	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	Get druggable targets OG5_130760	All targets in OG5_130760
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	corticotropin releasing hormone receptor 1	444 aa	445 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0713	0.0713
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.004	0.0713	0.1236
Entamoeba histolytica	CAAX prenyl protease, putative	0.0073	0.1853	0.3212
Plasmodium vivax	glutathione reductase, putative	0.0051	0.1081	0.4414
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0.0713	0.1693
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0121	0.0138
Trypanosoma cruzi	CAAX prenyl protease 1, putative	0.0073	0.1853	0.3212
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.1534	0.1534
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0116	0.3353	0.8814
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0036	0.0553	0.0553
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.031	0.0537
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0713	0.0815
Echinococcus multilocularis	CAAX prenyl protease 2	0.0185	0.5769	0.5769
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0921	0.0921
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0088	0.2392	0.2392
Echinococcus granulosus	geminin	0.0167	0.5158	0.5158
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.003	0.0371	0.1386
Brugia malayi	Thioredoxin reductase	0.0051	0.1081	0.1112
Entamoeba histolytica	Ran family GTPase	0.0021	0.0046	0.0079
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0088	0.2392	1
Entamoeba histolytica	CAAX amino terminal protease family	0.0038	0.0642	0.1112
Echinococcus granulosus	caax prenyl protease 1	0.0073	0.1853	0.1853
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.031	0.031
Toxoplasma gondii	thioredoxin reductase	0.0051	0.1081	0.4414
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0713	0.2845
Loa Loa (eye worm)	peptidase family M48 containing protein	0.0073	0.1853	0.1853
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0038	0.0642	0.1687
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0128	0.3804	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0095	0.2631	0.2631
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0046	0.0079
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0088	0.2392	1
Leishmania major	CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48	0.0073	0.1853	0.3212
Trichomonas vaginalis	glutaminase, putative	0.027	0.8745	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.1081	0.1081
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0046	0.0079
Loa Loa (eye worm)	glutathione reductase	0.0051	0.1081	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5769	0.5769
Entamoeba histolytica	CAAX amino terminal protease family	0.0038	0.0642	0.1112
Brugia malayi	Importin beta-1 subunit	0.0029	0.031	0.0319
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0088	0.2392	1
Toxoplasma gondii	CAAX amino terminal protease family protein	0.0038	0.0642	0.254
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.1534	0.2659
Schistosoma mansoni	hypothetical protein	0.0036	0.0553	0.0553
Trichomonas vaginalis	Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase	0.0073	0.1853	0.2119
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.1081	0.4414
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0116	0.3353	0.8814
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0046	0.0079
Trypanosoma brucei	metallo- peptidase, Clan M- Family M48	0.0073	0.1853	0.3212
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.004	0.0713	0.1236
Mycobacterium tuberculosis	Probable dehydrogenase	0.0116	0.3353	0.8814
Brugia malayi	glutathione reductase	0.0051	0.1081	0.1112
Mycobacterium ulcerans	integral membrane protein	0.0038	0.0642	0.0734
Toxoplasma gondii	exonuclease III APE	0.004	0.0713	0.2845
Plasmodium falciparum	protease, putative	0.0038	0.0642	0.254
Brugia malayi	Peptidase family M48 containing protein	0.0073	0.1853	0.1906
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.0038	0.0642	0.1687
Echinococcus multilocularis	geminin	0.0167	0.5158	0.5158
Schistosoma mansoni	hypothetical protein	0.0036	0.0553	0.0553
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.1534	0.6343
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0088	0.2392	1
Schistosoma mansoni	ran	0.0021	0.0046	0.0046
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0121	0.0138
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0921	0.0948
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0921	0.0921
Treponema pallidum	hypothetical protein	0.0038	0.0642	0.134
Trypanosoma brucei	trypanothione reductase	0.0051	0.1081	0.1874
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0713	0.1236
Mycobacterium ulcerans	glutaminase	0.027	0.8745	1
Echinococcus granulosus	importin subunit beta 1	0.0029	0.031	0.031
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0713	0.1236
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0221	0.7032	0.7032
Entamoeba histolytica	hypothetical protein	0.0023	0.0121	0.0209
Mycobacterium tuberculosis	Probable reductase	0.0116	0.3353	0.8814
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0058	0.133	0.2793
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0553	0.0553
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.1534	0.1534
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.1081	0.2843
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0221	0.7032	0.7032
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0058	0.133	0.3496
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.1534	0.1534
Trypanosoma cruzi	metallo- peptidase, Clan M- Family M48	0.0073	0.1853	0.3212
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0046	0.0046
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.031	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2392	0.2392
Plasmodium falciparum	glutathione reductase	0.0051	0.1081	0.4414
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0128	0.3804	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0713	0.1236
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.1081	0.1081
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.0185	0.5769	0.6597
Echinococcus granulosus	peptidase Clp S14 family	0.0058	0.133	0.133
Echinococcus granulosus	CAAX prenyl protease 2	0.0185	0.5769	0.5769
Echinococcus multilocularis	caax prenyl protease 1	0.0073	0.1853	0.1853
Schistosoma mansoni	peptidase Clp (S14 family)	0.0088	0.2392	0.2392
Toxoplasma gondii	hypothetical protein	0.0038	0.0642	0.254
Plasmodium vivax	importin-beta 2, putative	0.0029	0.031	0.1127
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0149	0.0171
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0121	0.0138
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0642	0.0734
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.1081	0.1874
Plasmodium falciparum	importin beta, putative	0.0029	0.031	0.1127
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1534	0.1754
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.003	0.0371	0.1386
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0128	0.3804	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0553	0.0553
Brugia malayi	Probable ClpP-like protease	0.0088	0.2392	0.2461
Onchocerca volvulus		0.0095	0.2631	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0116	0.3353	0.8685
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.1534	0.1534
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.0185	0.5769	1
Schistosoma mansoni	hypothetical protein	0.0306	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1534	0.1754
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0116	0.3353	0.8814
Loa Loa (eye worm)	hypothetical protein	0.0298	0.9721	0.9721
Brugia malayi	Trypsin family protein	0.0095	0.2631	0.2706
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0088	0.2392	0.2735
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.1081	0.1081
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0121	0.0209
Schistosoma mansoni	glutaminase	0.027	0.8745	0.8745
Leishmania major	trypanothione reductase	0.0051	0.1081	0.1874
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0921	0.0921
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0713	0.1236
Entamoeba histolytica	CAAX prenyl protease family	0.0185	0.5769	1
Echinococcus multilocularis	GPCR, family 2	0.0036	0.0553	0.0553
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0553	0.0569
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0298	0.9721	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0088	0.2392	0.2735
Echinococcus multilocularis	snurportin 1	0.0306	1	1
Brugia malayi	glutaminase DH11.1	0.027	0.8745	0.8996
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.0038	0.0642	0.1687
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0921	0.0921
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0046	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0149	0.0171
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0713	0.0815
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0921	0.0921
Schistosoma mansoni	importin beta-1	0.0029	0.031	0.031
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0046	0.0079
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0185	0.5769	0.5769
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0553	0.0569
Schistosoma mansoni	hypothetical protein	0.0036	0.0553	0.0553
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0088	0.2392	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0046	0.0047
Trichomonas vaginalis	ran, putative	0.0021	0.0046	0.0052
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0058	0.133	0.3496
Schistosoma mansoni	hypothetical protein	0.0167	0.5158	0.5158
Loa Loa (eye worm)	glutaminase 2	0.027	0.8745	0.8745
Leishmania major	GTP-binding protein, putative	0.0021	0.0046	0.0079
Schistosoma mansoni	ap endonuclease	0.004	0.0713	0.0713
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.0185	0.5769	1
Echinococcus granulosus	GPCR family 2	0.0036	0.0553	0.0553
Trypanosoma brucei	CAAX amino terminal protease, putative	0.0185	0.5769	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0553	0.0553
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.1534	0.1754
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0713	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2631	0.2631
Trichomonas vaginalis	Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase	0.0073	0.1853	0.2119
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	1	1
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0642	0.0734
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0088	0.2392	0.5888
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0112	0.3242	0.3335
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0185	0.5769	0.5769
Brugia malayi	CAAX amino terminal protease family protein	0.0185	0.5769	0.5935
Plasmodium vivax	protease, putative	0.0038	0.0642	0.254
Brugia malayi	latrophilin 2 splice variant baaae	0.0077	0.1997	0.2055
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0116	0.3353	0.8814
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0088	0.2392	0.2392
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.0185	0.5769	1
Mycobacterium tuberculosis	Probable integral membrane protein	0.0038	0.0642	0.1687
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2631	0.2631
Toxoplasma gondii	hypothetical protein	0.003	0.0371	0.1386
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1997	0.1997
Giardia lamblia	Hypothetical protein	0.0185	0.5769	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0095	0.2631	0.2631
Brugia malayi	RNA, U transporter 1	0.0081	0.2156	0.2218
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0713	0.0713
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0088	0.2392	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0088	0.2392	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0088	0.2392	1
Loa Loa (eye worm)	glutaminase	0.027	0.8745	0.8745
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0713	0.0734
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0713	0.0815
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.031	0.1127
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0713	0.2845
Toxoplasma gondii	hypothetical protein	0.0038	0.0642	0.254
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0921	0.0921
Plasmodium falciparum	thioredoxin reductase	0.0051	0.1081	0.4414
Mycobacterium tuberculosis	Probable oxidoreductase	0.0128	0.3804	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0553	0.0553
Schistosoma mansoni	ap endonuclease	0.004	0.0713	0.0713
Schistosoma mansoni	hypothetical protein	0.0077	0.1997	0.1997
Toxoplasma gondii	CAAX metallo endopeptidase	0.0073	0.1853	0.7702
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0713	0.1875
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0046	0.0046
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0112	0.3242	0.3242
Schistosoma mansoni	ran	0.0021	0.0046	0.0046
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0121	0.0209
Schistosoma mansoni	farnesylated-protein converting enzyme 1 (M48 family)	0.0073	0.1853	0.1853
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0058	0.133	0.133
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0921	0.0921
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.1534	0.4033
Schistosoma mansoni	hypothetical protein	0.0167	0.5158	0.5158
Loa Loa (eye worm)	hypothetical protein	0.0029	0.031	0.031
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0921	0.0921

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 10000 nM	Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor	ChEMBL.	15115386
Ki (binding)	> 10000 nM	Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor	ChEMBL.	15115386

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 130329