Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0065 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0065 | 1 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0065 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.4578 | 0.4578 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0046 | 0.4578 | 0.4578 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0065 | 1 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0065 | 1 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0065 | 1 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0065 | 1 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0065 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0065 | 1 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0046 | 0.4578 | 0.4578 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0065 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0065 | 1 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0065 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0065 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 800 uM | Inhibition against Leucyl aminopeptidase from pig kidney. | ChEMBL. | 10395480 |
IC50 (binding) | = 800 uM | Inhibition against Leucyl aminopeptidase from pig kidney. | ChEMBL. | 10395480 |
IC50 (binding) | > 1000 uM | Inhibition against membrane bound human aminopeptidase P | ChEMBL. | 10395480 |
IC50 (binding) | > 1000 uM | Inhibition against membrane bound human aminopeptidase P | ChEMBL. | 10395480 |
IC50 (binding) | = 1200 uM | Activity against membrane bound rat aminopeptidase P | ChEMBL. | 10395480 |
IC50 (binding) | = 1200 uM | Activity against membrane bound rat aminopeptidase P | ChEMBL. | 10395480 |
IC50 (binding) | > 2000 uM | Inhibition against membrane bound monkey aminopeptidase P | ChEMBL. | 10395480 |
IC50 (binding) | > 2000 uM | Inhibition against Aminopeptidase P from bovine. | ChEMBL. | 10395480 |
IC50 (binding) | > 2000 uM | Inhibition against cytosolic Aminopeptidase P from human heart. | ChEMBL. | 10395480 |
IC50 (binding) | > 2000 uM | Inhibition against Aminopeptidase P from E. coli. | ChEMBL. | 10395480 |
IC50 (binding) | > 2000 uM | Inhibition against Prolidase from pig kidney. | ChEMBL. | 10395480 |
IC50 (binding) | > 2000 uM | Inhibition against membrane bound monkey aminopeptidase P | ChEMBL. | 10395480 |
IC50 (binding) | > 2000 uM | Inhibition against cytosolic Aminopeptidase P from human heart. | ChEMBL. | 10395480 |
IC50 (binding) | > 2000 uM | Inhibition against Prolidase from pig kidney. | ChEMBL. | 10395480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.