Detailed information for compound 1308522

Basic information

Technical information
  • TDR Targets ID: 1308522
  • Name: ZINC00386309
  • MW: 281.288 | Formula: C11H11N3O4S
  • H donors: 3 H acceptors: 6 LogP: 1.08 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(C)c(c(n1)O)NS(=O)(=O)c1ccccc1
  • InChi: 1S/C11H11N3O4S/c1-7-9(10(15)13-11(16)12-7)14-19(17,18)8-5-3-2-4-6-8/h2-6,14H,1H3,(H2,12,13,15,16)
  • InChiKey: LXEANPCGBLLUHG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • STK112544
  • MLS000548670
  • SMR000172375
  • BAS 08315053
  • N-(2,4-Dihydroxy-6-methyl-pyrimidin-5-yl)-benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0201 0.0961
Schistosoma mansoni protein kinase 0.0058 0.1018 0.1385
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0367 0.0367
Leishmania major glucose transporter, lmgt3 0.0032 0.0413 0.4053
Echinococcus granulosus aurora kinase A 0.0058 0.1018 0.4867
Schistosoma mansoni hypothetical protein 0.0034 0.0459 0.0624
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4053
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0058 0.1018 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0414 0.1978
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0058 0.1018 0.1018
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.2092 0.3196
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0274
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0367 0.0367
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0367 0.0561
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.4053
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2092 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.1855
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0414 0.1978
Toxoplasma gondii exonuclease III APE 0.0018 0.0086 0.0131
Leishmania major protein kinase, putative 0.0058 0.1018 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0029 0.0039
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4053
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0367 0.0367
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0367 0.3606
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0086 0.0117
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0201 0.1975
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0086 0.0844
Schistosoma mansoni glutaminase 0.033 0.7351 1
Loa Loa (eye worm) AUR protein kinase 0.0058 0.1018 0.1385
Entamoeba histolytica hypothetical protein 0.0023 0.0201 0.1235
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0388 0.3811
Onchocerca volvulus 0.0295 0.6539 1
Echinococcus granulosus GPCR family 2 0.0016 0.0029 0.0137
Echinococcus granulosus General substrate transporter 0.009 0.175 0.8364
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0086 0.0411
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0414 0.0563
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0414 0.1978
Leishmania major glucose transporter, lmgt2 0.0032 0.0413 0.4053
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.4053
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.1018 0.1385
Brugia malayi hypothetical protein 0.0295 0.6539 0.8895
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0086 0.0117
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0509 0.4999
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0086 0.0117
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2092 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0029 0.0137
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0201 0.0307
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 1 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0414 0.0414
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0058 0.1018 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0086 0.0086
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.4053
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.2092 0.2846
Trypanosoma brucei aurora B kinase 0.0058 0.1018 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0134 0.0182
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0086 0.0844
Loa Loa (eye worm) hypothetical protein 0.003 0.0367 0.0499
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0414 0.1978
Schistosoma mansoni glucose transport protein 0.0104 0.2092 0.2846
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0414 0.0414
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0459 0.0624
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.4053
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0119 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0414 0.0633
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.083 0.1129
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0528
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0528
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0086 0.0844
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0029 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.0561
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0086 0.7211
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0274
Brugia malayi serine/threonine-protein kinase 6 0.0058 0.1018 0.1385
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0201 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0414 0.1978
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.1018 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0528
Brugia malayi hypothetical protein 0.002 0.0116 0.0157
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0058 0.1018 0.4867
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0039
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0086 0.0411
Trypanosoma cruzi hexose transporter, putative 0.0018 0.007 0.0691
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0201 0.0201
Plasmodium falciparum serine/threonine protein kinase, putative 0.0058 0.1018 0.1018
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0086 0.0117
Leishmania major glucose transporter, lmgt1 0.0032 0.0413 0.4053
Leishmania major protein kinase, putative 0.0032 0.0414 0.4064
Entamoeba histolytica protein kinase, putative 0.0058 0.1018 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.1855
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0414 0.1978
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0274
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0201 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0561
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0039
Schistosoma mansoni glucose transport protein 0.0104 0.2092 0.2846
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0039
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0414 0.0414
Schistosoma mansoni ap endonuclease 0.0018 0.0086 0.0117
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4053
Brugia malayi Cam kinase protein 1 0.0032 0.0414 0.0563
Schistosoma mansoni protein kinase 0.0032 0.0414 0.0563
Schistosoma mansoni glucose transport protein 0.0104 0.2092 0.2846
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0414 0.0563
Loa Loa (eye worm) hypothetical protein 0.0032 0.0414 0.0563
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4053
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0039
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.3046
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0414 0.0563
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0414 0.0563
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4053
Trypanosoma brucei glucose transporter 2A 0.0032 0.0413 0.4053
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0201 0.0961
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0414 0.0414
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0413 0.4053
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0357 0.1707
Entamoeba histolytica protein kinase , putative 0.0058 0.1018 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.0561
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0509 0.4999
Schistosoma mansoni protein kinase 0.0032 0.0414 0.0563
Loa Loa (eye worm) hypothetical protein 0.005 0.083 0.1129
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0086 0.0086
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3602 0.3602
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0201 0.1975
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.4053
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0367 0.3606
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0388 0.0528
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0414 0.0414
Schistosoma mansoni ap endonuclease 0.0018 0.0086 0.0117
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0509 0.4999
Echinococcus multilocularis GPCR, family 2 0.0016 0.0029 0.0137
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0388 0.324
Brugia malayi serine/threonine kinase 12 0.0058 0.1018 0.1385
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.083 0.1129
Loa Loa (eye worm) glutaminase 0.033 0.7351 1
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0509 0.0509
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3602 0.5502
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0414 0.0414
Plasmodium falciparum protein kinase 7 0.0296 0.6546 0.6546
Loa Loa (eye worm) glutaminase 2 0.033 0.7351 1
Trichomonas vaginalis AGC family protein kinase 0.0058 0.1018 0.1385
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0119 1
Loa Loa (eye worm) AUR protein kinase 0.0058 0.1018 0.1385
Echinococcus multilocularis aurora kinase A 0.0058 0.1018 0.4867
Brugia malayi glutaminase DH11.1 0.033 0.7351 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2092 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0086 1
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0509 0.0509
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0414 0.1978
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0086 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.083 0.1129
Loa Loa (eye worm) hypothetical protein 0.0295 0.6539 0.8895
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0201 0.0201
Entamoeba histolytica protein kinase, putative 0.0058 0.1018 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2092 1
Toxoplasma gondii protein kinase, putative 0.0296 0.6546 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0086 0.0844
Trichomonas vaginalis AGC family protein kinase 0.0058 0.1018 0.1385
Brugia malayi hypothetical protein 0.003 0.0367 0.0499
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0528
Schistosoma mansoni hypothetical protein 0.0104 0.2092 0.2846
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0414 0.0414
Echinococcus multilocularis General substrate transporter 0.009 0.175 0.8364
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0086 0.0844
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0414 0.0633
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0414 0.4064
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0357 0.1707
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0201 0.1975
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0058 0.1018 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0029 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.0561
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3602 0.3602
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0528
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2092 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0086 0.0117
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4053
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0367 0.3606
Trypanosoma brucei glucose transporter 1E 0.0032 0.0413 0.4053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0251 0.0342
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0509 0.0778
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0039
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2092 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0528
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.2092 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0274
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4053
Plasmodium falciparum hexose transporter 0.0104 0.2092 0.2092
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0029 0.0039
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0034 0.0459 0.0624
Entamoeba histolytica protein kinase, putative 0.0032 0.0414 0.3517
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0414 0.0414
Trypanosoma cruzi aurora B kinase, putative 0.0058 0.1018 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2092 1
Trypanosoma cruzi hexose transporter 0.0032 0.0413 0.4053
Entamoeba histolytica protein kinase, putative 0.0032 0.0414 0.3517
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.4053
Trichomonas vaginalis AGC family protein kinase 0.0058 0.1018 0.1385
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0058 0.1018 0.4867
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0414 0.0563
Toxoplasma gondii aurora kinase 0.0058 0.1018 0.1556
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.0561
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0388 1
Mycobacterium ulcerans glutaminase 0.033 0.7351 1
Giardia lamblia Aurora kinase 0.0058 0.1018 1
Loa Loa (eye worm) sugar transporter 0.0104 0.2092 0.2846
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0561
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0029 0.0137
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0509 0.4999
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0201 0.1975
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0509 0.4999
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0274
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0414 0.1978
Schistosoma mansoni protein kinase 0.0032 0.0414 0.0563
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0414 0.0633
Brugia malayi serine/threonine protein kinase 6 0.0058 0.1018 0.1385
Trichomonas vaginalis AGC family protein kinase 0.0058 0.1018 0.1385
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0561
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0029 0.0039
Leishmania major hypothetical protein, conserved 0.003 0.0367 0.3606
Loa Loa (eye worm) AUR protein kinase 0.0058 0.1018 0.1385
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.4053
Plasmodium vivax hexose transporter 0.0104 0.2092 0.2092
Brugia malayi Sugar transporter family protein 0.0104 0.2092 0.2846
Trichomonas vaginalis glutaminase, putative 0.033 0.7351 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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