Detailed information for compound 1311460

Basic information

Technical information
  • TDR Targets ID: 1311460
  • Name: N-(3,4-dimethoxyphenyl)-2-methylsulfanylpyrid ine-3-carboxamide
  • MW: 304.364 | Formula: C15H16N2O3S
  • H donors: 1 H acceptors: 2 LogP: 2.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)NC(=O)c1cccnc1SC
  • InChi: 1S/C15H16N2O3S/c1-19-12-7-6-10(9-13(12)20-2)17-14(18)11-5-4-8-16-15(11)21-3/h4-9H,1-3H3,(H,17,18)
  • InChiKey: VNJULVDLGNGIED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3,4-dimethoxyphenyl)-2-methylsulfanyl-pyridine-3-carboxamide
  • N-(3,4-dimethoxyphenyl)-2-(methylthio)-3-pyridinecarboxamide
  • N-(3,4-dimethoxyphenyl)-2-(methylthio)nicotinamide
  • ZINC02638770
  • T5266091
  • MLS001018856
  • SMR000385426

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 1 0.018 0.5216 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0025 0.023 0.5
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0025 0.023 0.0346
Schistosoma mansoni hypothetical protein 0.0041 0.0759 0.0711
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0025 0.023 0.018
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0024 0.0217 0.0217
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0025 0.023 0.023
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0025 0.023 0.0346
Onchocerca volvulus 0.0033 0.0484 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.023
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0025 0.023 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Loa Loa (eye worm) PDE1B protein 0.0025 0.023 0.023
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0025 0.023 0.018
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0025 0.023 0.0346
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.023 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0025 0.023 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.023 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0024 0.0217 0.032
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 0.5
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0025 0.023 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.023 0.018
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0025 0.023 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0024 0.0217 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0025 0.023 0.0346
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.023 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.023 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1369 0.1369
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Echinococcus multilocularis lamin 0.0033 0.0484 0.0838
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0025 0.023 0.023
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0484 0.0484
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0025 0.023 0.5
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Onchocerca volvulus 0.0033 0.0484 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1369 0.1369
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Echinococcus multilocularis muscleblind protein 0.018 0.5216 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0024 0.0217 0.032
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0051 0.0051
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.023 0.018
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0025 0.023 0.023
Mycobacterium leprae Possible regulatory protein 0.0024 0.0217 0.5
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0025 0.023 0.0346
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.023 0.018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0217
Brugia malayi PAS domain containing protein 0.0024 0.0217 0.0217
Schistosoma mansoni single-minded 0.0024 0.0217 0.0166
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0025 0.023 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0025 0.023 0.0346
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0025 0.023 1
Leishmania major hypothetical protein, conserved 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.018 0.5216 0.5216
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0025 0.023 0.023
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0025 0.023 0.018
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0025 0.023 0.018
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0025 0.023 0.018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0025 0.023 0.0346
Echinococcus granulosus intermediate filament protein 0.0033 0.0484 0.0838
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.023 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0024 0.0217 0.032
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0025 0.023 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1369 0.1369
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0051 0.0051
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0051 0.0051
Brugia malayi intermediate filament protein 0.0033 0.0484 0.0484
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Brugia malayi hypothetical protein 0.0024 0.0217 0.0217
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0025 0.023 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.023 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0484 0.0484
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0025 0.023 0.0346
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Leishmania major hypothetical protein, conserved 0.0025 0.023 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0025 0.023 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0025 0.023 0.0346
Echinococcus multilocularis musashi 0.0033 0.0484 0.0838
Brugia malayi Muscleblind-like protein 0.018 0.5216 0.5216
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.023 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0759 0.0759
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.9211 0.9211
Loa Loa (eye worm) hypothetical protein 0.0032 0.0465 0.0465
Giardia lamblia Hypothetical protein 0.0025 0.023 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0051
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0025 0.023 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Schistosoma mansoni intermediate filament proteins 0.0033 0.0484 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.023 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0484 0.0484
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0484 0.0484
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.033 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.9211 0.9211
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.033 1 1
Echinococcus granulosus muscleblind protein 0.018 0.5216 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0025 0.023 0.0346
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.5216 0.5216
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0025 0.023 1
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.023 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0025 0.023 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1369 0.1369
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 0.5
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0025 0.023 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0025 0.023 0.0346
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.023
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.023 0.5
Plasmodium falciparum phosphodiesterase delta, putative 0.0025 0.023 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0025 0.023 1
Echinococcus granulosus lamin 0.0033 0.0484 0.0838
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.023 0.5
Echinococcus granulosus aryl hydrocarbon receptor 0.0024 0.0217 0.032
Echinococcus multilocularis lamin dm0 0.0033 0.0484 0.0838
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0024 0.0217 0.0166
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0025 0.023 0.0346
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0025 0.023 0.0346
Loa Loa (eye worm) hypothetical protein 0.0041 0.0759 0.0759
Plasmodium vivax phosphodiesterase gamma, putative 0.0025 0.023 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Schistosoma mansoni lamin 0.0033 0.0484 0.0435
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.033 1 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0025 0.023 0.0346
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0025 0.023 0.018
Echinococcus granulosus lamin dm0 0.0033 0.0484 0.0838
Schistosoma mansoni lamin 0.0033 0.0484 0.0435
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.9211 0.9211
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 0.5
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0025 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0217
Giardia lamblia hypothetical protein 0.0025 0.023 0.5
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0025 0.023 0.0346
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0025 0.023 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0025 0.023 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0025 0.023 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 6.3096 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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