Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1776 | 0.1913 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1776 | 0.1657 |
Giardia lamblia | Kinesin-5 | 0.0139 | 0.1155 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0144 | 0.1242 |
Schistosoma mansoni | hypothetical protein | 0.0932 | 0.8679 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0139 | 0.1155 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0139 | 0.1155 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0139 | 0.1155 | 1 |
Onchocerca volvulus | 0.0033 | 0.0144 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0144 | 0.1242 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0144 | 0.1242 |
Entamoeba histolytica | kinesin, putative | 0.0139 | 0.1155 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0144 | 0.1242 |
Echinococcus granulosus | geminin | 0.0205 | 0.1776 | 0.1657 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0144 | 0.1242 |
Schistosoma mansoni | kinesin eg-5 | 0.0139 | 0.1155 | 0.1185 |
Brugia malayi | Kinesin motor domain containing protein | 0.0139 | 0.1155 | 1 |
Plasmodium vivax | kinesin-5 | 0.0139 | 0.1155 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.1071 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.0144 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0138 | 0.1193 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1776 | 0.1913 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.058 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.